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. 2010 Feb 1;28(8):1287–1293. doi: 10.1200/JCO.2009.25.7246

Table A1.

Association of 51 SNPs in ABC Transporter Genes With Recurrence-Free Survival

Gene and SNP ID Chromosomal Location Position in Gene Allele*
 No. of Patients With Genotype
 Minor Allele Frequency
 Hardy-Weinberg Equilibrium P Log-Rank P
Event
 No Event
1 2 11 12 22 11 12 22 Event No Event
ABCB1
    rs10278483 87169901 Intron 1 T C 34 7 0 192 44 4 0.09 0.11 .57 .47
    rs2157929 87140076 Intron 1 T C 31 8 2 170 62 7 0.15 0.16 .35 .47
    rs10233247 87109774 Intron 1 A G 27 8 0 189 50 2 0.11 0.11 .37 .84
    rs1978095 87089577 Intron 1 T C 23 13 5 134 94 12 0.28 0.25 .83 .77
    rs13233308 87082896 Intron 1 C T 15 16 10 75 117 48 0.44 0.44 .49 .69
    rs4148732 87071985 Intron 1 A G 32 9 0 178 58 4 0.11 0.14 .60 .32
    rs2188524 87068371 Intron 1 A G 34 7 0 192 48 0 0.09 0.10 .069 .43
    rs3213619 87068129 Exon 2 (5′ UTR) T C 36 5 0 211 29 0 0.06 0.06 .28 .58
    rs3789243 87058822 Intron 4 C T 15 18 8 93 107 39 0.41 0.39 .29 .93
    rs1202184 87051837 Intron 5 A G 20 16 5 102 119 19 0.32 0.33 .12 .62
    rs17327442 87050926 Intron 5 T A 31 10 0 184 52 4 0.12 0.13 .84 .65
    rs1202172 87048910 Intron 5 T G 33 8 0 204 35 0 0.10 0.07 .16 .77
    rs10256836 87038709 Intron 5 G C 29 12 0 166 68 6 0.15 0.17 .50 .23
    rs2235018 87037301 Intron 6 A G 24 15 2 153 82 5 0.23 0.19 .14 .69
    rs4148734 87031533 Intron 8 C T 28 13 0 162 72 6 0.16 0.18 .32 .32
    rs868755 87027866 Intron 9 A C 14 20 6 68 126 44 0.40 0.45 .28 .98
    rs2235046 87012002 Intron 17 A G 17 19 5 88 126 26 0.35 0.37 .068 .45
    rs1922242 87011603 Intron 17 A T 19 18 4 101 114 25 0.32 0.34 .41 .40
    rs3789246 87005963 Intron 20 G A 30 9 2 166 63 9 0.16 0.17 .19 .70
    rs2032582 86998554 Exon 22 (Ala893Thr/Ser) G A/T 13 22 6 82 124 35 0.41 0.40 .21 .53
    rs7787082 86994987 Intron 22 G A 13 21 6 92 105 40 0.41 0.39 .43 .91
    rs2373588 86991096 Intron 22 C T 14 20 6 76 100 61 0.40 0.47 .034 .38
    rs2235067 86987858 Intron 23 G A 38 3 0 226 14 0 0.04 0.03 .60 .96
    rs1002205 86979110 Intron 26 C G 14 21 6 102 105 33 0.40 0.36 .61 .61
    rs1045642 86976581 Exon 27 (Ile1145Ile) C T 11 24 6 77 116 47 0.44 0.44 .84 .50
    rs2235047 86976468 Intron 27 T G 14 22 5 94 109 36 0.39 0.38 .90 .97
    rs6979885 86975397 Intron 27 G A 29 12 0 173 62 5 0.15 0.15 .55 .41
    rs1882478 86974954 Intron 27 C T 11 22 8 64 127 49 0.46 0.47 .28 .48
ABCC2
    rs12268782 101523996 5′ upstream region G A 24 15 2 174 61 6 0.23 0.15 .83 .082
    rs2804398 101548624 Intron 7 T A 30 8 3 175 58 8 0.17 0.15 .062 .79
    rs2756109 101548736 Intron 7 G T 10 22 9 110 102 28 0.49 0.33 .58 .0031
    rs2273697 101553805 Exon 10 (Ile417Val) G A 32 7 1 196 43 2 0.11 0.10 .89 .66
    rs11190291 101556000 Intron 11 C T 32 7 1 196 43 2 0.11 0.10 .89 .66
    rs2002042 101577921 Intron 19 C T 19 18 4 114 101 26 0.32 0.32 .66 .83
    rs3740065 101595683 Intron 29 A G 26 14 1 86 117 38 0.20 0.40 .94 .00020†
    rs12762549 101610761 3′ downstream region G C 12 20 8 100 110 30 0.45 0.35 .98 .074
    rs2862691 101612513 3′ downstream region C T 17 19 5 138 86 17 0.35 0.25 .48 .042
    rs11598781 101623010 3′ downstream region C T 17 19 5 136 90 15 0.35 0.25 .92 .036
    rs11190303 101625199 3′ downstream region C T 27 13 0 103 103 34 0.16 0.36 .31 .00048†
ABCG2
    rs2622604 89297948 Intron 1 C T 31 9 1 200 41 0 0.13 0.09 .32 .45
    rs6532049 89286550 Intron 1 C T 31 8 1 167 67 7 0.13 0.17 .78 .36
    rs2622624 89288430 Intron 1 G A 22 16 2 137 88 16 0.25 0.25 .86 .85
    rs1564481 89280289 Intron 1 C T 19 18 3 92 117 32 0.30 0.38 .54 .083
    rs2231137 89280138 Exon 2 (Val12Met) G A 24 15 2 164 69 8 0.23 0.18 .87 .30
    rs2231142 89271347 Exon 5 (Gln141Lys) C A 15 23 3 121 97 22 0.35 0.29 .84 .17
    rs11931123 89269132 Intron 5 T G 31 9 0 172 63 6 0.11 0.16 .90 .42
    rs1871744 89258653 Intron 6 T C 22 18 1 137 88 16 0.24 0.25 .90 1.00
    rs2622621 89249944 Intron 9 G C 18 18 4 105 102 34 0.33 0.35 .32 .74
    rs7681519 89246864 Intron 10 G C 27 9 4 175 63 3 0.21 0.14 .85 .51
    rs2622611 89244050 Intron 10 G T 32 4 5 163 68 10 0.17 0.18 .020 .92
    rs2231164 89234881 Intron 14 A G 12 21 8 68 121 52 0.45 0.47 .84 .71

Abbreviations: SNP, single nucleotide polymorphism; ID, identification; UTR, untranslated region.

*

Major allele in no event group was defined as allele 1.

†

Statistically significant after Bonferroni's correction based on 51 independent effective tests (P < .00098).