Table 4.
Pharmacokinetics Parameters of Irinotecan, SN-38, SN-38G, GR, and BI
| Irinotecan Dose (mg/m2) | No. of Patients | Irinotecan AUC (μmol/L*h) |
Irinotecan CL (L/h) |
SN-38 AUC (μmol/L*h) |
SN-38G AUC (μmol/L*h) |
GR |
BI (μmol/L*h) |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | ||
| 215 | 6 | 24.44 | 4.63 | 16.76 | 3.65 | 0.65 | 0.15 | 3.53 | 0.98 | 5.74 | 2.53 | 4.61 | 1.19 |
| 260 | 8 | 25.62 | 7.51 | 18.95 | 6.53 | 0.91 | 0.44 | 3.11 | 0.67 | 3.80 | 1.04 | 7.28 | 2.81 |
| 310 | 9 | 30.91 | 7.78 | 18.51 | 4.67 | 0.86 | 0.19 | 3.89 | 0.91 | 4.37 | 0.63 | 7.14 | 2.79 |
| 370 | 8 | 34.22 | 6.29 | 18.52 | 4.05 | 1.01 | 0.22 | 5.11 | 0.80 | 5.32 | 1.58 | 6.83 | 2.05 |
| 420 | 2 | 43.44 | 7.74 | 17.36 | 5.62 | 1.44 | 0.37 | 5.03 | 1.66 | 3.45 | 0.27 | 12.70 | 3.24 |
| Spearman correlation coefficient | 33 | 0.60 | 0.09 | 0.55 | 0.60 | −0.05 | 0.39 | ||||||
| P | .0002 | .6 | .001 | .0002 | .8 | .02 | |||||||
Abbreviations: GR, glucuronidation ratio; BI, biliary index; SD, standard deviation.