Table 4.

Relative Rate of Endocrine and Cardiac Complications and Subsequent Neoplasms Across Racial/Ethnic Groups of Childhood Cancer Survivors

	Subsequent Neoplasms*		Subsequent Malignancies		Cardiovascular		Endocrine
	RR (95% CI)	P	RR (95% CI)	P	RR (95% CI)	P	RR (95% CI)	P
Adjusted for clinical/demographic variables†
NHW	Ref		Ref		Ref		Ref
NHB	0.6 (0.4 to 0.9)	.009	0.8 (0.5 to 1.4)	.50	1.9 (1.2 to 2.9)	.005	0.8 (0.5 to 1.4)	.48
Hispanic	0.8 (0.6 to 1.1)	.21	1.1 (0.7 to 1.6)	.62	1.2 (0.8 to 1.8)	.41	1.5 (1.1 to 2.1)	.02
Adjusted for clinical/demographic variables and treatment‡
NHW	Ref		Ref		Ref		Ref
NHB	0.5 (0.3 to 0.8)	.005	0.8 (0.5 to 1.3)	.37	1.8 (1.1 to 2.7)	.01	0.8 (0.5 to 1.3)	.39
Hispanic	0.8 (0.6 to 1.1)	.25	1.1 (0.7 to 1.6)	.66	1.2 (0.8 to 1.8)	.46	1.5 (1.1 to 2.2)	.01
Adjusted for clinical/demographic variables, treatment, and SES§
NHW	Ref		Ref		Ref		Ref
NHB	0.6 (0.4 to 0.9)	.01	0.8 (0.5 to 1.4)	.45	1.6 (1.0 to 2.4)	.04	0.9 (0.5 to 1.5)	.63
Hispanic	0.8 (0.6 to 1.2)	.29	1.1 (0.7 to 1.6)	.77	1.1 (0.7 to 1.6)	.77	1.6 (1.2 to 2.3)	.005
Adjusted for clinical/demographic variables, treatment, SES, and CVRF||
NHW	Ref		Ref		Ref		Ref
NHB	0.6 (0.4 to 0.9)	.02	0.9 (0.5 to1.4)	.59	1.5 (1.0 to 2.3)	.08	0.9 (0.5 to 1.4)	.59
Hispanic	0.8 (0.6 to 1.1)	.25	1.0 (0.7 to 1.6)	.91	1.0 (0.6 to 1.5)	.86	1.6 (1.2 to 2.3)	.005

Abbreviations: CVRF, cardiovascular risk factors; NHB, non-Hispanic black; NHW, non-Hispanic white; Ref, reference; RR, relative rate; SES, socioeconomic status.

^*Subsequent neoplasm included both malignancies and benign subsequent neoplasms.

^†Clinical/demographic variables include sex, age at diagnosis, diagnosis, treatment era, and attained age as natural cubic splines.

^‡Treatment includes radiation therapy, alkylating agent cyclophosphamide equivalent dose, and anthracycline score.

^§SES includes education, annual household income, and health insurance as time-dependent variables.

||CVRF include obesity, diabetes, hypertension, and dyslipidemia.