Table 2.

SIRs and AER of SMN

Parameter	Patients	Person-Years	Observed SMN	Expected SMN	SIR	95% CI	AER*	95% CI
Any SMN	110	2,143.4	21	0.916	22.9	14.2 to 35	93.7	56.4 to 145.5
Sex
Male	75	1,435.3	11	0.505	21.8	10.9 to 39	73.1	34.7 to 133.6
Female	35	708.1	10	0.392	25.5	12.2 to 46.9	135.7	62.2 to 254.2
Age at HL diagnosis, years
< 11	53	1,057.8	4	0.357	11.2	3.1 to 28.7	34.4	6.9 to 93.4
≥ 11	57	1,085.6	17	0.557	30.5	17.8 to 48.9	151.5	86.1 to 245.6
SMN site
Leukemia	110	2,143.4	4	0.044	90.9	24.8 to 232.8	18.5	4.9 to 47.6
Solid tumor	110	2,143.4	17	0.86	19.8	11.5 to 31.7	75.3	42.2 to 123.0
Thyroid	110	2,143.4	5	0.094	53.2	17.3 to 124.1	22.9	7.1 to 54.0
Sarcoma	110	2,143.4	4	0.045	88.9	24.2 to 227.6	18.5	4.9 to 47.6
Breast (females)	35	708.1	6	0.082	72.3	26.5 to 157.3	83.6	29.9 to 183.3

Abbreviations: SIR, standardized incidence ratio; AER, absolute excess risk; SMN, second malignant neoplasm; HL, Hodgkin's lymphoma.

^*Calculated per 10,000 person-years.