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. 2016 May 18;13:111. doi: 10.1186/s12974-016-0577-8

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© Marignier et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Human IgG chronically infused in the rat brain ventricle widely diffused in the neural tissues. a Detection of human IgG in the rat brain, spinal cord, and optic nerve using immunohistochemistry (rat infused with IgG^AQP4+2, D7 as and example). Scale bar 10 μm. Hip hippocampus, Cx cortex, CC corpus callosum, MB midbrain, ME median eminence, 3V third ventricle. b Detection of human immunoglobulin IgH and IgL chains (black arrows) accumulated in neural tissues of NMO-rats (received IgG-NMO) and Control-rats (received control IgG) ((asterisk) D7 and D14) using Western blot (actin as protein deposition control, same blot. Control: neural tissue from rat receiving saline buffer)