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. 2016 May 18;13:111. doi: 10.1186/s12974-016-0577-8

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© Marignier et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Motor impairment in NMO-rat. Motor skills of the NMO-rats (red symbols, n = 10, rats infused with IgG^AQP4+2) as compared to the Saline-rats (white symbols, n = 10). a Rotarod experiment measuring the latency to fall from the rotating rod at D3, D7, D10, D14, and D21 after IgG infusion, expressed as percent of D0 scores (latencies). The NMO-rats showed impairment in this task and fell much sooner from the rod than the Saline-rats. b Walking experiment measuring deviation from the linear trajectory initially chosen by the rat at D7, D14, and D21, expressed as percent of D0 shifts (*p < 0.05; **p < 0.01, ANOVA followed by post hoc tests). c Western blot analysis of the spinal cord of all rats at D21: altered expression of AQP4, GLT1, and pNF-H in the NMO-rats compared to the Control-rats