. 2016 May 19;8:56. doi: 10.1186/s13073-016-0302-3

Table 1.

Empirical type I error rates for MiSPU and aMiSPU for scenario 1 with a binary outcome

	MiSPU_w(2)	MiSPU_w(∞)	aMiSPU_w	aMiSPU_u	aMiSPU
X ⊥ ⊥Z, adjust X	0.052	0.050	0.052	0.049	0.048
X ⊥ ⊥Z, no adjust X	0.051	0.051	0.052	0.049	0.049
X∼Z, adjust X	0.043	0.038	0.043	0.049	0.040
X∼Z, no adjust X	0.091 ^a	0.119 ^a	0.112 ^a	0.053	0.088 ^a

The type I error rate was evaluated for situations in which the covariates were independent of the OTUs (X ⊥ ⊥Z) or correlated with the OTUs (X∼Z) based on 10,000 simulated data sets at α=0.05

^aInflated type I error rates