Table 1.
Regions | BA | t-value | Cluster size | Peak voxel coordinates (MNI) | ||
---|---|---|---|---|---|---|
X | Y | Z | ||||
Left DLPFC | ||||||
Positive coupling PD | ||||||
Precuneus | 7 | 4.19 | 66 | 3 | −61 | 31 |
Right DMPFC | 9 | 4.17 | 22 | 9 | 50 | 19 |
Positive coupling HC | ||||||
PCC | 23 | 4.82 | 361 | −3 | −55 | 22 |
Precuneus | 31 | 4.58 | −9 | −58 | 31 | |
PCC | 23 | 4.43 | 9 | −55 | 19 | |
Left angular gyrus | 39 | 4.36 | 126 | −45 | −73 | 22 |
Negative coupling PD | ||||||
Left SFG | 6 | 4.99 | 76 | −9 | −19 | 73 |
Right SFG | 6 | 4.58 | 37 | 18 | −19 | 70 |
Right primary somatosensory cortex | 2 | 4.17 | 14 | 30 | −37 | 70 |
Right SFG | 6 | 3.72 | 26 | 12 | −10 | 55 |
Interaction effect positive coupling: HC > PD (masked with main effect of positive coupling HC) | ||||||
Right insular cortex | 13 | 3.91 | 15 | 42 | 5 | −11 |
Interaction effect negative coupling: PD < HC (masked with main effect of negative coupling PD) | ||||||
Left SFG | 6 | 4.50 | 57 | −6 | −22 | 70 |
4.19 | −15 | −19 | 73 | |||
3.89 | −9 | −7 | 73 | |||
Right SFG | 6 | 3.70 | 13 | 51 | −7 | 52 |
Right SFG | 6 | 4.14 | 24 | 18 | −19 | 70 |
Right primary Somatosensory cortex | 1 | 4.14 | 15 | 30 | −37 | 70 |
Right insular cortex | 13 | 3.91 | 57 | 42 | 5 | −11 |
Right DLPFC | ||||||
Positive coupling PD | ||||||
Right DMPFC | 9 | 3.89 | 10 | 9 | 53 | 19 |
Positive coupling HC | ||||||
PCC | 31 | 4.47 | 197 | −3 | −61 | 22 |
23 | 4.06 | 6 | −58 | 19 | ||
31 | 3.97 | −3 | −52 | 28 | ||
Left angular gyrus | 39 | 4.01 | 137 | −45 | −76 | 25 |
4.00 | −36 | −70 | 19 | |||
3.76 | −45 | −61 | 16 | |||
Negative coupling PD | ||||||
Left SFG | 6 | 3.65 | 11 | −18 | −22 | 73 |
Results of the connectivity analyses: comparison of the PD and HC groups on the successful shift > successful repeat contrast. All areas were significant at an uncorrected threshold of p < .001, with an extent threshold of 10 voxels
HC healthy controls, PD Parkinson’s disease, BA Brodmann area