Table 3.
Prostate transcriptomic signatures up-regulated by 1% AGN feeding in male C57BL/6 mice.
Genes in mouse prostate up-regulated by AGN diet feeding for 6 weeks
| Up-regulated in AGN fed mice >60% (Bold font >2 fold) | AGN-regulated | |||
|---|---|---|---|---|
| Gene Symbol | Definition | AGN/Control | Functional category | in NE-Ca |
| Zhang MolCar2014 | ||||
| Actb | actin, beta | 0.97 | House keeping gene | |
| Gapdh | glyceraldehyde-3-phosphate dehydrogenase | 1.00 | House keeping gene | |
| Cyp4a12a | cytochrome P450, family 4, subfamily a, polypeptide 12a | 3.13 | Drug metabolism, Phase I | |
| Cyp4a14 | cytochrome P450, family 4, subfamily a, polypeptide 14 | 1.61 | Drug metabolism, Phase I | |
| Cyp2a5 | cytochrome P450, family 2, subfamily a, polypeptide 5 | 2.50 | Drug metabolism, Phase I | |
| Cyp2c37 | cytochrome P450, family 2. subfamily c, polypeptide 37 | 1.83 | Drug metabolism, Phase I | |
| Cyp2d9 | cytochrome P450, family 2, subfamily d, polypeptide 9 | 1.89 | Drug metabolism, Phase I | |
| Cyp2e1 | cytochrome P450, family 2, subfamily e, polypeptide 1 | 1.65 | Drug metabolism, Phase I | |
| Cyp3a11 | cytochrome P450, family 3, subfamily a, polypeptide 11 | 1.60 | Drug metabolism, Phase I | |
| Cyp8b1 | cytochrome P450, family 8, subfamily b, polypeptide 1 | 1.67 | Drug metabolism, Phase I | |
| Gsta3 | glutathione S-transferase, alpha 3 | 1.77 | Drug metabolism, Phase II, loss in PCa | |
| Gstm5 | glutathione S-transferase, mu 5 | 1.62 | Drug metabolism, Phase II, lost in PCa | |
| Mgst1 | glutathione S-transferase 1, microsomal | 1.93 | Drug metabolism, Phase II, loss in PCa | |
| Sult1a1 | sulfotransferase family 1A, phenol-preferring, member 1 | 1.70 | Drug metabolism, Phase II | |
| Ugt2b36 | UDP glucuronosyltransferase 2 family, polypeptide B36 | 1.92 | Drug metabolism, Phase II | |
| Saa3 | serum amyloid A 3 | 5.19 | Inflammation, adiposity | |
| Kng1 | kininogen 1 | 3.09 | Inflammation, coagulation | Dn88 |
| Ahsg | alpha-2-HS-glycoprotein (fetuin-A) | 2.07 | Inflammation, inhibitory | |
| Alox5ap | arachidonate 5-lipoxygenase activating protein | 2.04 | Inflammation | |
| Crygc | crystallin, gamma C | 1.69 | Inflammation, inhibitory | |
| Hpgd | hydroxyprostaglandin dehydrogenase 15 (NAD) | 1.78 | Inflammation, inhibitory | |
| Hpx | hemopexin | 2.14 | Inflammation, heme chelator, inhibitory | |
| Ifit3 | interferon-induced protein with tetratricopeptide repeats 3 | 1.88 | Inflammation | |
| Sgk1 | serum/glucocorticoid regulated kinase 1 | 1.61 | Inflammation | |
| Lcn2 | lipocalin 2 | 3.48 | Immunity, innate, inflammation | |
| Arg1 | arginase 1, liver | 1.65 | Immunity, infection | |
| C3 | complement component 3 | 1.64 | Immunity | |
| Cd52 | CD52 antigen | 2.13 | Immunity | |
| Cotl1 | coactosin-like 1 | 1.88 | Immunity | |
| Cuzd1 | CUB and zona pellucida-like domains 1 | 2.84 | Immunity, auto-immune | |
| Defb11 | defensin beta 11 | 1.71 | Immunity, innate | |
| Defb2 | defensin beta 2 | 2.03 | Immunity, innate | |
| Defb42 | defensin beta 42 | 2.47 | Immunity, innate | |
| Defb43 | defensin beta 43 | 2.19 | Immunity, innate | |
| Emb | embigin | 1.64 | Immunity | |
| Il4i1 | interleukin 4 induced 1 | 1.71 | Immunity, suppressive | |
| Ly6a | lymphocyte antigen 6 complex, locus A | 1.97 | Immunity | |
| Pglyrp1 | peptidoglycan recognition protein 1 | 1.84 | Immunity, innate | |
| Sirpa | signal-regulatory protein alpha | 1.64 | Immunity | |
| Plau | plasminogen activator, urokinase | 2.30 | Immunity, Wound healing | |
| Apoa1 | apolipoprotein A-I | 4.38 | Lipid metabolism, PPAR | |
| Apoa2 | apolipoprotein A-II | 14.07 | Lipid metabolism, PPAR | |
| Apoc3 | apolipoprotein C-III | 3.88 | Lipid metabolism, PPAR | |
| Apoc1 | apolipoprotein C-I | 2.18 | Lipid metabolism, PPAR | |
| Apoc4 | apolipoprotein C-IV | 2.21 | Lipid metabolism, PPAR | |
| Apoe | apolipoprotein E | 2.43 | Lipid metabolism, PPAR | |
| Acaa1b | acetyl-Coenzyme A acyltransferase 1B | 2.11 | Lipid metabolism, PPAR | |
| Mup1 | major urinary protein 1, (usually secreted by liver, male sexual attractiveness) | 5.93 | Lipid metabolism, glucose homeostasis | |
| Mup3 | major urinary protein 3, (usually secreted by liver, male sexual attractiveness) | 4.98 | Lipid metabolism, glucose homeostasis | |
| Mup2 | major urinary protein 2, (usually secreted by liver, male sexual attractiveness) | 2.08 | Lipid metabolism, glucose homeostasis | |
| Akr1b7 | aldo-keto reductase family 1, member B7 | 2.07 | Lipid, adiposity | |
| Ces3 | carboxylesterase 3 | 1.86 | Lipid metabolism | |
| Degs1 | degenerative spermatocyte homolog 1 (Drosophila) | 1.69 | Lipid metabolism, adiposity | |
| Es1 | esterase 1 | 1.70 | Lipid metabolism | |
| Fads1 | fatty acid desaturase 1 | 2.03 | Lipid metabolism, synthesis | |
| Gde1 | glycerophosphodiester phosphodiesterase 1 | 1.64 | Lipid, phospholipid and G-proteins | |
| Mir16 | membrane interacting protein of RGS16 | 1.78 | Lipid, phospholipid and G-proteins | |
| Ckb | creatine kinase, brain | 1.62 | Energy metabolism | |
| Ckm | creatine kinase, muscle | 2.07 | Energy metabolism | |
| Ckmt2 | creatine kinase, mitochondrial 2 | 1.67 | Energy metabolism | |
| Hmgcs2 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 | 1.69 | Energy metabolism, mitochondria | |
| Pgam2 | phosphoglycerate mutase 2 (2,3-diphosphoglycerate synthesis; Hb oxygenation) | 2.50 | Energy metabolism, glycolysis diversion | |
| Atp2a1 | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | 6.52 | Muscle | Up50 |
| Atp2a3 | ATPase, Ca++ transporting, ubiquitous (Sarcoplasmic/ER Calcium ATPases, SERCA) | 1.63 | Muscle | |
| Atp1b3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 1.79 | Muscle/ion transport | |
| Cox6a2 | cytochrome c oxidase, subunit VI a, polypeptide 2 | 2.86 | Muscle/heart, mitochondria ATP | |
| Myl1 | myosin, light polypeptide 1 | 6.05 | Muscle | Up3 |
| Mylpf | myosin light chain, phosphorylatable, fast skeletal muscle | 3.02 | Muscle | Up79 |
| Myh8 | myosin, heavy polypeptide 8, skeletal muscle | 2.90 | Muscle | Up30 |
| Myl3 | myosin, light polypeptide 3 | 2.49 | Muscle | Up62 |
| Mb | myoglobin | 2.15 | Muscle | Up34 |
| Myh11 | myosin, heavy polypeptide 11 | 1.65 | Muscle | |
| Mylk | myosin, light polypeptide kinase | 1.81 | Muscle | |
| Myom1 | myomesin 1 | 1.69 | Muscle | |
| Tnni2 | troponin I, skeletal, fast 2 | 5.52 | Muscle | Up21 |
| Tnnc2 | troponin C2, fast | 3.07 | Muscle | Up20 |
| Tnnt3 | troponin T3, skeletal, fast | 2.72 | Muscle | |
| Tpm2 | tropomyosin 2, beta | 2.40 | Muscle | Up75 |
| Acta1 | actin, alpha 1, skeletal muscle | 1.81 | Muscle | Up5 |
| Acta2 | actin, alpha 2, smooth muscle, aorta | 1.69 | Muscle | |
| Adssl1 | adenylosuccinate synthetase like 1 | 1.73 | Muscle | |
| Eno3 | enolase 3, beta muscle | 2.06 | Muscle | |
| Pdlim3 | PDZ and LIM domain 3 | 1.94 | Muscle | |
| Rpl3l | ribosomal protein L3-like | 1.84 | Muscle specific | |
| Tcap | titin-cap | 2.58 | Muscle | |
| Ttn | titin | 1.69 | Muscle | |
| Ttr | transthyretin | 4.84 | Neuroprotection | Dn74 |
| Pvalb | parvalbumin | 3.70 | Neurogenesis | |
| Gldc | glycine decarboxylase | 1.74 | Neurogenesis | |
| Inmt | indolethylamine N-methyltransferase | 1.82 | Neuroprotection, transmitter | |
| Rhobtb3 | Rho-related BTB domain containing 3 | 1.79 | Neuroprotection, vesicular transport | |
| Scin | scinderin | 1.77 | Neuroprotection, vesicles | |
| Serpina1b | serine (or cysteine) preptidase inhibitor, clade A, member 1b | 5.85 | Tumor suppressor, anti-invason | |
| Serpina1d | serine (or cysteine) peptidase inhibitor, clade A, member 1d | 3.98 | Tumor suppressor, anti-invason | |
| Serpina1c | serine (or cysteine) peptidase inhibitor, clade A, member 1c | 3.36 | Tumor suppressor, anti-invason | |
| Serpina1f | serine (or cysteine) peptidase inhibitor, clade A, member 1f | 3.26 | Tumor suppressor, anti-invason | |
| Serpine2 | serine (or cysteine) peptidase inhibitor, clade E, member 2 | 1.60 | Tumor suppressor, anti-invason | |
| Spink8 | serine peptidase inhibitor, Kazal type 8 | 2.46 | Tumor suppressor, anti-invason | |
| Spink10 | serine peptidase inhibitor, Kazal type 10 | 1.62 | Tumor suppressor, anti-invason | |
| Spink11 | serine peptidase inhibitor, Kazal type 11 | 1.84 | Tumor suppressor, anti-invason | |
| Ambp | alpha 1 microglobulin/bikunin (inter-alpha-trypsin inhibitor family) | 3.20 | Tumor suppressor, anti-invason | |
| Wfdc10 | WAP four-disulfide core domain 10 (protease inhibitor) | 3.19 | Tumor suppressor, anti-invason | |
| Wfdc15b | WAP four-disulfide core domain 15B (protease inhibitor) | 2.48 | Tumor suppressor, anti-invason | |
| Camk2n1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 1.69 | Tumor suppressor | |
| Cdh16 | cadherin 16 | 1.63 | Tumor suppressor, kidney specific | |
| Cdo1 | cysteine dioxygenase 1, cytosolic (Taurine production) | 1.83 | Tumor suppressor, methylation | |
| Mat1a | methionine adenosyltransferase I, alpha (Methionine-Cysteine metabolism) | 2.23 | Tumor suppressor, methylation | |
| Elf5 | E74-like factor 5 | 1.96 | Tumor suppressor, anti-EMT | |
| Igfbp7 | insulin-like growth factor binding protein 7 | 1.64 | Tumor suppressor | |
| Lrg1 | leucine-rich alpha-2-glycoprotein 1 | 1.79 | Tumor suppressor, anti-EMT | |
| Samd9l | sterile alpha motif domain containing 9-like, transcript variant 1 | 1.88 | Tumor suppressor, methylation | |
| Aqp1 | aquaporin 1 | 1.66 | Solute/ion transport | |
| Aqp9 | aquaporin 9 | 2.10 | Solute/ion transport | |
| Clcnkb | chloride channel Kb | 1.79 | Solute/ion transport | |
| Fxyd4 | FXYD domain-containing ion transport regulator 4 | 2.98 | Solute/ion transport | |
| Ltf | lactotransferrin | 2.36 | Iron transport | |
| Scara3 | scavenger receptor class A, member 3 | 1.85 | Solute transport, polyanionic | |
| Slco1b2 | solute carrier organic anion transporter family, member 1b2 | 1.76 | Solute/ion transport | |
| Slco2a1 | solute carrier organic anion transporter family, member 2a1 | 2.52 | Solute/ion transport | |
| Trf | transferrin | 1.97 | Iron transport | |
| Ccnd1 | cyclin D1 (in prostate epithelium acts as AR transcriptional co-repressor) | 2.18 | Prostate AR supressor | |
| Clu | clusterin; testosterone-repressed prostate message-2 gene (TRPM-2) | 2.24 | Prostate survival protein | |
| Crisp1 | cysteine-rich secretory protein 1 (male fertility) | 1.67 | Prostate function | |
| Svs2 | seminal vesicle secretory protein 2 (male fertility) | 2.57 | Prostate function | |
| Qsox1 | quiescin Q6 sulfhydryl oxidase 1 | 1.87 | Redox, anti-oxidative | Dn57 |
| Sh3bgrl3 | SH3 domain binding glutamic acid-rich protein-like 3 | 1.71 | Redox, cardioprotective | |
| Mgp | matrix Gla protein | 1.83 | Vascular health, anti-angiogenesis | |
| Fga | fibrinogen, alpha polypeptide | 1.73 | Vascular health, clotting | |
| Fgg | fibrinogen, gamma polypeptide | 1.85 | Vascular health, clotting | |
| Cxcl12 | chemokine (C-X-C motif) ligand 12 | 1.64 | Vascular health, maturation | |
| B3gnt8 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 | 1.74 | Oncogene-like, invasion | |
| Hoxb7 | homeo box B7 | 1.74 | Oncogene-like | |
| Mia1 | melanoma inhibitory activity 1 | 1.75 | Oncogene-like, invasion | |
| Sphk1 | sphingosine kinase 1 | 1.64 | Oncogene-like, pro-survival | |
| Tspan8 | tetraspanin 8 | 2.10 | Oncogene-like, invasion | Up65 |