Table 5.
Normalized organ weight and plasma biochemistry of male CD-1 mice treated with AGN extract by daily i.p. injection for 4 weeks. N=6 mice per group.
male mice
| Body weight g | Normalized organ weight (mg/g) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Liver | Kidney | Heart | Lung | Thymus | Spleen | Prostate | |||
| Control, vehicle | Mean | 37.22 | 48.27 | 18.03 | 5.08 | 6.40 | 1.20 | 3.57 | 3.00 |
| SE | 1.03 | 1.62 | 0.58 | 0.19 | 0.35 | 0.18 | 0.47 | 0.15 | |
| 100mg/kg AGN | Mean | 34.98 | 47.57 | 15.55 | 4.85 | 5.85 | 1.19 | 2.43 | 3.06 |
| SE | 1.04 | 1.87 | 0.44 | 0.14 | 0.30 | 0.12 | 0.22 | 0.20 | |
| 200mg/kg AGN | Mean | 35.33 | 48.03 | 15.52 | 4.94 | 6.67 | 1.09 | 2.84 | 2.39 |
| SE | 0.75 | 0.60 | 0.61 | 0.29 | 0.56 | 0.07 | 0.20 | 0.28 | |
| 300mg/kg AGN | Mean | 33.27 | 51.92 | 16.29 | 5.26 | 6.62 | 1.25 | 2.38 | 3.06 |
| SE | 0.96 | 2.32 | 0.36 | 0.14 | 0.30 | 0.43 | 0.42 | 0.39 | |
| ANOVA significance | Y | N | Y | N | N | N | N | N | |
|
|
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|---|---|---|---|---|---|---|
| Plasma biochemistry | ||||||
| ALP (U/L) | AST (U/L) | ALT (U/L) | BUN (mg/dL) | Creatinine (mg/dL) | ||
|
| ||||||
| Control, vehicle | Mean | 55.0 | 137.7 | 41.7 | 31.9 | 0.20 |
| SE | 4.2 | 8.0 | 5.3 | 3.8 | 0.01 | |
| 100mg/kg AGN | Mean | 68.3 | 169.3 | 31.0 | 28.9 | 0.19 |
| SE | 3.7 | 25.1 | 2.9 | 2.0 | 0.03 | |
| 200mg/kg AGN | Mean | 55.3 | 161.7 | 36.7 | 20.5 | 0.20 |
| SE | 14.7 | 6.0 | 2.8 | 1.0 | 0.03 | |
| 300mg/kg AGN | Mean | 60.3 | 112.3 | 45.7 | 26.3 | 0.21 |
| SE | 6.1 | 6.7 | 8.1 | 0.8 | 0.01 | |
| ANOVA significance | N | N | N | Y | N | |