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. Author manuscript; available in PMC: 2016 May 19.
Published in final edited form as: Am J Chin Med. 2015 Sep 22;43(6):1211–1230. doi: 10.1142/S0192415X1550069X

Figure 3.

Figure 3

Effect of competitive CYP 2C19 inhibitor (+)-N-3-benzylnirvanol (NBN) and competitive CYP 3A4 inhibitor ketoconazole (KCZ) on in vitro metabolism of D (Panels a–d) and DA (Panels e–h) by human liver microsome (HLM). D or DA was added to the reactions concurrently with solvent control (a & e), NBN (b & f), ketoconazole (c & g), NBN and ketoconazole (d & h). Reactions were terminated after 60 minutes. UV detection wavelength was 330nm for HPLC-chromatograms. M6 and N8 correspond to respective mono-oxygenated metabolite of D and DA in HLM incubation we previously identified (Li et al., 2013a).