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. 2016 Apr 5;6(4):e772. doi: 10.1038/tp.2016.38

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Effects of minocycline (MINO) on IL-1β-positive cells in the hippocampus of stressed offspring born to control or gestationally immune-challenged mothers. Pregnant mice were injected with 1 mg kg⁻¹ poly(I:C) (POL) or physiological saline (control (CON)), and the resulting offspring were subjected to sub-chronic stress (S+) during peripubertal maturation. During the stress procedure, half of the animals received MINO treatment (30 mg kg⁻¹ per day, per os in drinking water), and the other half vehicle (VEH; = regular tap water) treatment. (a) The bar plot shows the stereological estimates of IL-1β-positive cells. *P<0.05, N=5 per group. (b) The photomicrographs (b1–b3) show representative IL-1β immunoreactivity (indicated by the black arrowheads) in the hippocampal formation visualized with a Nissl/IL-1β double-staining. Note that IL-1β immunoreactivity was present in cells displaying noticeable immunoreactive processes (b1 and b2) and in cells with no immunoreactive processes (b3). All data are means±s.e.m.