Table 2. Comparison of measured volumes of each ROI between patients with recent onset schizophrenia and healthy controls who underwent [11C]DPA-713 PET.
| ROI | HC (n=14)a | SZ (n=12)a | Pb |
|---|---|---|---|
| Hippocampus | 8.87 (0.90) | 8.41 (0.64) | 0.143 |
| Amygdala | 3.84 (0.51) | 3.36 (0.43) | 0.015 |
| Frontal cortex | 170.70 (16.43) | 157.55 (24.83) | 0.134 |
| Temporal cortex | 101.61 (11.14) | 93.36 (16.46) | 0.158 |
| Parietal cortex | 111.96 (13.67) | 103.90 (19.30) | 0.241 |
| Occipital cortex | 45.36 (5.22) | 44.08 (7.38) | 0.620 |
| Cingulate cortex | 20.86 (2.58) | 18.25 (2.09) | 0.009 |
| Insular cortex | 29.31 (3.92) | 28.89 (4.23) | 0.794 |
| Total gray matter | 633.20 (63.45) | 602.17 (86.13) | 0.315 |
| Intracranial volume | 1454.10 (157.73) | 1434.68 (139.87) | 0.742 |
Abbreviations: HC, healthy controls; PET, positron emission tomography; ROI, region of interest; SZ, patients with recent onset of schizophrenia.
a
Regional volumes reported in mm3 for the patients and control subjects who underwent PET imaging.
b
P-values for t-tests across the eight selected ROIs, as well as the total gray matter and the total intracranial volume.
Accounting for the eight selected ROIs, the threshold for significance was P<0.05/8=0.006.