Table 2. Crude and adjusted odds ratios with their 95% CIs comparing levels of CRP among children with ASD, DD and GP controls—the early markers for autism study: sample 1.

	Developmental outcome			ASD vs GP		DD vs GP
	ASD (n=84)	DD (N=47)	GP (N=148)	Crude OR (95% CI)	AORa (95% CI)	Crude OR (95% CI)	AORb (95% CI)
CRP as a continuous variable (mean concentration in mg dl−1 and s.d.)	2.00 (2.04)	3.09 (2.80)	2.63 (2.33)	0.88 (0.73–1.05)	0.97 (0.78–1.20)	1.09 (0.87–1.37)	1.02 (0.80–1.31)
CRP values by quartile (range in mg dl−1)
Q1 (0.05–0.615)	24 (28.6)	10 (21.3)	37 (25.0)	1	1	1	1
Q2 (0.616–2.393)	37 (44.1)	14 (29.8)	37 (25.0)	1.54 (0.78–3.06)	1.87 (0.89–3.92)	1.40 (0.55–3.55)	1.26 (0.49–3.25)
Q3 (2.394–3.821)	7 (8.3)	7 (14.9)	37 (25.0)	0.29 (0.11–0.76)	0.36 (0.13–1.00)	0.70 (0.24–2.04)	0.57 (0.19–1.75)
Q4 (3.822–10.253)	16 (19.1)	16 (34.0)	37 (25.0)	0.63 (0.28–1.40)	0.91 (0.35–2.40)	1.50 (0.60–3.77)	1.14 (0.40–3.24)
CRP values by quintile (range in mg dl−1)
Q1 (0.05–0.455)	18 (21.4)	9 (19.2)	29 (19.6)	1	1	1	1
Q2 (0.456–1.291)	24 (28.6)	8 (17.0)	30 (20.3)	1.29 (0.58–2.86)	1.36 (0.58–3.16)	0.86 (0.29–2.53)	0.79 (0.27–2.36)
Q3 (1.292–2.904)	20 (23.8)	10 (21.3)	30 (20.3)	1.07 (0.48–2.43)	1.37 (0.56–3.32)	1.07 (0.38–3.02)	0.87 (0.29–2.55)
Q4 (2.905–4.390)	6 (7.1)	8 (17.0)	30 (20.3)	0.32 (0.11–0.93)	0.42 (0.14–1.27)	0.86 (0.29–2.53)	0.74 (0.25–2.24)
Q5 (4.391–10.253)	16 (19.1)	12 (25.5)	29 (19.6)	0.83 (0.35–1.96)	1.33 (0.47–3.80)	1.22 (0.44–3.39)	0.83 (0.26–2.68)

Abbreviations: AOR, adjusted odds ratio; ASD, autism spectrum disorder; CI, confidence interval; CRP, C-reactive protein; DD, developmental delays; GP, general population.

^aAdjusted for sex, birth month, birth year, maternal ethnicity and weight at blood draw.

^bAdjusted for maternal ethnicity, maternal race and weight at blood draw.