Table 3. Crude and adjusted odds ratios with their 95% CIs comparing levels of CRP among children with ASD, DD and GP controls–the early markers for autism study: sample 2.

	Developmental outcome			ASD vs GP		DD vs GP
	ASD (n=416)	DD (N=188)	GP (N=432)	Crude OR (95% CI)	AORa (95% CI)	Crude OR (95% CI)	AORb (95% CI)
CRP as a continuous variable (mean concentration in mg dl−1 and s.d.)	3.13 (3.75)	3.93 (3.96)	3.63 (5.16)	0.83 (0.73–0.95)	0.83 (0.72–0.97)	1.14 (0.96–1.36)	0.95 (0.78–1.17)
CRP values by quartile (range in mg dl−1)
Q1 (0.04–1.32)	147 (35.3)	47 (25.0)	110 (25.5)	1	1	1	1
Q2 (1.33–2.40)	100 (24.0)	42 (22.3)	107 (24.8)	0.70 (0.48–1.01)	0.71 (0.49–1.04)	0.92 (0.56–1.51)	0.75 (0.45–1.26)
Q3 (2.41–4.48)	82 (19.7)	48 (25.3)	106 (24.5)	0.57 (0.39–0.83)	0.57 (0.38–0.85)	1.06 (0.65–1.72)	0.76 (0.45–1.28)
Q4 (4.49–78.68)	87 (20.9)	51 (27.1)	109 (25.2)	0.59 (0.40–0.86)	0.58 (0.38–0.89)	1.10 (0.68–1.76)	0.68 (0.40–1.17)
CRP values by quintile (range in mg dl−1)
Q1 (0.04–1.00)	103 (24.8)	36 (19.2)	87 (20.1)	1	1	1	1
Q2 (1.01–1.88)	102 (24.5)	30 (16.0)	89 (20.6)	0.98 (0.65–1.47)	0.98 (0.65–1.48)	0.82 (0.46–1.44)	0.69 (0.38–1.24)
Q3 (1.89–3.08)	77 (18.5)	37 (19.7)	85 (19.7)	0.76 (0.50–1.15)	0.83 (0.53–1.29)	1.05 (0.61–1.82)	0.72 (0.40–1.30)
Q4 (3.09–5.04)	64 (15.4)	37 (19.7)	86 (19.9)	0.62 (0.40–0.96)	0.63 (0.39–1.00)	1.04 (0.60–1.80)	0.68 (0.38–1.23)
Q5 (5.05–78.68)	70 (16.8)	48 (25.3)	85 (19.7)	0.69 (0.45–1.06)	0.70 (0.44–1.14)	1.37 (0.81–2.31)	0.83 (0.46–1.50)

Abbreviations: AOR, adjusted odds ratio; ASD, autism spectrum disorder; CI, confidence interval; CRP, C-reactive protein; DD, developmental delays; GP, general population.

^aAdjusted for sex, birth month, birth year, maternal ethnicity and weight at blood draw and parity.

^bAdjusted for maternal ethnicity, maternal race and weight at blood draw.