Table 1. Genetic correlations between neuroticism documented in UK Biobank and mental and physical health-related traits curated from GWAS consortia.

Trait Category	Traits from GWAS consortia	Neuroticism (UKB) (n=108 038)			Neuroticism (GPC) (n=63 661)
		rg	s.e.	P	rg	s.e.	P
Mental health	ADHD	0.060	0.082	0.4681	0.090	0.191	0.6371
	Alzheimer's disease	0.118	0.080	0.1378	0.089	0.177	0.6147
	Alzheimer's disease (500 kb)	0.091	0.063	0.1514	0.051	0.145	0.7262
	Anorexia nervosa	0.174	0.04	2.36 × 10−5	0.319	0.082	9.56 × 10−5
	Bipolar disorder	0.083	0.052	0.1096	0.162	0.101	0.1091
	Major depressive disorder	0.659	0.087	2.75 × 10−14	1.073	0.199	7.15 × 10−8
	Schizophrenia	0.212	0.050	2.39 × 10−5	0.198	0.068	0.0033
Physical health	Blood pressure: diastolic	−0.011	0.078	0.887	−0.108	0.091	0.2363
	Blood pressure: systolic	−0.051	0.060	0.3959	–0.008	0.083	0.925
	BMI	−0.036	0.028	0.1921	0.046	0.055	0.4077
	Coronary artery disease	0.104	0.053	0.0489	0.221	0.104	0.0331
	Longevity	−0.083	0.081	0.3011	0.002	0.163	0.9888
	Rheumatoid arthritis	−0.0816	0.05	0.103	−0.093	0.123	0.4463
	Smoking status	0.113	0.05	0.0205	0.124	0.090	0.1657
	Type 2 diabetes	−0.145	0.07	0.0389	0.044	0.107	0.6837

Abbreviations: ADHD, attention-deficit hyperactivity disorder; BMI, body mass index; GPC, Genetics of Personality Consortium; GWAS, genome-wide association study; UKB, UK Biobank.

Statistically significant P-values (after false discovery rate correction—P<0.0033) are shown in bold.