Table 2. Associations between polygenic risk scores for mental and physical health-related traits created from GWAS consortia summary data and neuroticism in UK Biobank participants, adjusted for age, sex, assessment centre, genotyping batch and array, and 10 principal components for population stratification.

Trait category	Traits from GWAS consortia	Neuroticism (n=108 038)
		Threshold	β	R2	P
Mental health	ADHD	0.05	0.0045	2.06 × 10−5	0.1292
	Alzheimer's disease	0.05	−0.0065	4.16 × 10−5	0.0312
	Anorexia nervosa	0.1	0.0054	2.87 × 10−5	0.0735
	Bipolar disorder	0.5	0.0171	0.0003	1.71 × 10−8
	Borderline personality	1	0.0150	0.0002	5.43 × 10−7
	Major depressive disorder	1	0.0357	0.0012	1.23 × 10−31
	Negative affect (anxiety)	1	0.00949	8.99 × 10−5	1.55 × 10−3
	Neuroticism (GPC)	0.5	0.0433	0.0020	1.77 × 10−47
	Schizophrenia	0.1	0.0359	0.0012	7.88 × 10−32
Physical health	Blood pressure: diastolic	0.1	−0.0047	2.20 × 10−5	0.1167
	Blood pressure: systolic	0.05	−0.0016	2.51 × 10−6	0.5969
	BMI	0.01	−0.0095	9.00 × 10−5	0.0015
	Coronary artery disease	0.1	0.0109	0.00012	0.0003
	Longevity	0.05	−0.0051	2.55 × 10−5	0.0917
	Rheumatoid arthritis	0.5	−0.0007	5.09 × 10−5	0.8266
	Smoking status	0.5	0.0167	0.0002	2.48 × 10−7
	Type 2 diabetes	0.01	−0.0031	9.67 × 10−6	0.2989

Abbreviations: ADHD, attention-deficit hyperactivity disorder; BMI, body mass index; GPC, Genetics of Personality Consortium; GWAS, genome-wide association study.

The associations between the polygenic risk scores and neuroticism with the largest effect size (threshold) are presented. Statistically significant P-values (after false discovery rate correction—P<0.0065) are shown in bold.