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. 2016 Mar 1;6(3):e746. doi: 10.1038/tp.2015.226

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Rates of psychiatric outcomes by genotype with increasing trauma severity. Childhood trauma (a–e) and non-childhood trauma (f–j) were binned into severity categories based on the number and types of trauma encountered. Because we identified a genotype × gender interaction for PTSD, males (solid lines) and females (dashed lines) are shown separately. Significant P-values from the discovery cohort for main effects of rs6295G-allele are indicated on the appropriate graph. NS, not significant; PTSD, posttraumatic stress disorder.