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. 2016 Mar 1;6(3):e746. doi: 10.1038/tp.2015.226

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Copyright © 2016 Macmillan Publishers Limited

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Relative allelic expression from the rs6295C-allele in the PFC of controls and MDD/suicide patients. (a) Relatively less HTR1A mRNA is produced from the C-allele of MDD patients compared with nonpsychiatric controls. (b) Two models that may explain the reduced penetrance of rs6295 in MDD. Previous work suggests that Deaf1 levels are impacted by stress, and decreased Deaf1 would be expected to preferentially decrease expression from the C-allele. Alternatively, epigenetic changes that inhibit access of transcription factors to the rs6295 locus would also neutralize the effects of this SNP. MDD, major depressive disorder; PFC, prefrontal cortex; SNP, single-nucleotide polymorphism.