Table 7. Logistic regression modeling of rs6295 and non-childhood trauma.
Non-childhood trauma |
Psychiatric hospitalization |
Suicide attempt |
Past substance abuse |
Depression |
PTSD |
|||||
---|---|---|---|---|---|---|---|---|---|---|
OR | P | OR | P | OR | P | OR | P | OR | P | |
Discovery sample | ||||||||||
rs6295GG | 1.655 | 0.015 | 1.591 | 0.026 | 1.484 | 0.029 | 1.209 | 0.258 | 1.328 | 0.095 |
Male sex | 0.615 | 0.022 | 0.300 | <0.001 | 1.703 | 0.002 | 0.742 | 0.078 | 0.851 | 0.336 |
Age | 1.201 | 0.002 | 1.229 | 0.001 | 1.437 | <0.001 | 1.109 | 0.018 | 1.077 | 0.094 |
Age2 | 0.998 | 0.005 | 0.998 | 0.001 | 0.996 | <0.001 | 0.999 | 0.015 | 0.999 | 0.072 |
Disability | 2.454 | <0.001 | 2.178 | 0.001 | 1.136 | 0.534 | 0.998 | 0.993 | 1.178 | 0.429 |
Moderate traumaa | 1.964 | 0.332 | 4.601 | 0.053 | 1.361 | 0.510 | 1.238 | 0.586 | 1.862 | <0.001 |
Severe traumaa | 4.246 | 0.018 | 7.502 | 0.006 | 2.485 | 0.020 | 2.016 | 0.035 | 7.276 | <0.001 |
Test sample | ||||||||||
rs6295GG | 2.231 | 0.007 | 1.436 | 0.230 | 1.163 | 0.574 | ||||
Male sex | 0.830 | 0.540 | 0.506 | 0.029 | 1.620 | 0.056 | ||||
Age | 1.386 | <0.001 | 1.307 | 0.001 | 1.434 | <0.001 | ||||
Age2 | 0.996 | <0.001 | 0.997 | 0.002 | 0.996 | <0.001 | ||||
Disability | 3.163 | 0.001 | 1.946 | 0.064 | 1.396 | 0.274 | ||||
Moderate traumaa | 1.578 | 0.613 | 1.055 | 0.966 | 1.177 | 0.862 | ||||
Severe traumaa | 2.254 | 0.291 | 5.799 | 0.090 | 5.311 | 0.031 |
Abbreviation: PTSD, posttraumatic stress disorder.
Relative to no trauma.
Odds ratios (OR) and P-values (P) for P<0.05 are shown in bold.