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. 2016 Mar 15;6(3):e760. doi: 10.1038/tp.2016.13

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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CBX reduces ethanol intake in rats in an operant self-administration paradigm. (a) Acute, systemic administration of CBX decreases operant alcohol self-administration both in dependent (dep) and nondependent (nondep) rats. (b) CBX did not influence water intake in any group. (c) Acute, systemic administration of CBX does not affect operant self-administration of saccharin-sweetened water. Rats were given CBX (0, 20 and 40 mg kg⁻¹ or 0 and 40 mg kg⁻¹; intraperitoneally) 90 min before alcohol (10%, w/v), water or saccharin (0.004%) self-administration (30 min session; fixed-ratio 1). The data represent means and s.e.m. *P<0.05, significant difference from respective vehicle; ⁺P<0.05, significant difference from vehicle (saline)-treated nondependent rats. N=9–10 per group.