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. 2016 Mar 15;6(3):e760. doi: 10.1038/tp.2016.13

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Copyright © 2016 Macmillan Publishers Limited

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Activity of 18α-glycyrrhetinic acid and 18β-glycyrrhetinic on mouse and human 11β-HSD1 and 11β-HSD2. We tested the IC50 of α- and β-glycyrrhetinic acid (GA) against human and mouse 11β-HSD1 and 11β-HSD2 by means of homogeneous time-resolved fluorescence (HTRF) assays. (a and c) α−GA yielded IC50 values of 532.1 nm for human 11β-HSD1 and 6.63 μm for mouse 11β-HSD1. (b and d) α−GA yielded IC50 values of 942.6 nm for human 11β-HSD2 and 159.7 nm for mouse 11β-HSD2. (e and g) β−GA yielded IC50 values of 232.3 nm for human 11β-HSD1 and 5.85 μm for mouse 11β-HSD1. (f and h) β−GA yielded IC50 values of 674.5 nm for human 11β-HSD2 and 79.7 nm for mouse 11β-HSD2.