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. 2016 Mar 15;6(3):e760. doi: 10.1038/tp.2016.13

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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CBX and αCBX reduce ethanol intake in mice in the drinking-in-the-dark (DID) paradigm. (a and b) CBX reduced ethanol intake in the DID binge-like drinking paradigm. (a) CBX effect on ethanol intake in the first 2 h of the 4-h drinking session (F_3,30=26.00, P<0.0001); (b) CBX effect on ethanol intake for the 4-h drinking session (F_3,30=10.82, P<0.0001); (c) αCBX effect on ethanol intake in the first 2 h of the 4-h drinking session (F_3,86=15.66, P<0.0001); (d) αCBX effect on ethanol intake for the 4-h drinking session (F_3,86=18.51, P<0.0001). The effects of CBX and αCBX were more pronounced in the first 2 h of the session, suggesting an effect on initiation of drinking. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001, significant difference from respective saline vehicle (N=11–15).