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. 2016 Mar 1;6(3):e749. doi: 10.1038/tp.2016.26

Figure 2.

Figure 2

JZL184 impairs extinction of cue-conditioned freezing behavior. (a) Schematic diagram of the experimental paradigm and drug treatments. (b) Effects of JZL184 treatment prior to extinction on baseline freezing and conditioned freezing to the first tone presentation. (c) Freezing levels during acquisition of cue-conditioned fear (d and e) Effects of JZL184 on short-term extinction of conditioned freezing on days 1 and 2 of extinction training. (f) Freezing levels during acquisition of cue-conditioned fear. (g and h) Effects of Rimonabant and JZL184 co-administration on JZL184-induced short-term extinction impairment on days 1 and 2 of extinction. ††P<0.01, †††P<0.001 significant effect of drug treatment by two-way ANOVA. **P<0.01, ***P<0.001 significantly different from vehicle treatment by unpaired two-tailed t-test (bar graphs). Error bars represent s.e.m. (b–e) n=20 mice per group. (f–h) n=10 mice per group. ANOVA, analysis of variance.