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. 2016 Mar 1;6(3):e749. doi: 10.1038/tp.2016.26

Figure 6.

Figure 6

JZL184 microinfusion into the BLA enhances retention of cue-conditioned fear. (a) Schematic of JZL184 BLA-specific microinfusion paradigm and drug-free retrieval. (b) Coronal representation of BLA microinjection targeting for each subject determined by post hoc analysis of injection sites. (c) Effects of JZL184 microinfusion into the BLA on freezing during cue-conditioning and short-term extinction sessions. (d) Effects of JZL184 on freezing during a drug-free retrieval test. (e) Schematic of JZL184 CeA-specific microinfusion paradigm and drug-free retrieval. (f) Coronal representation of CeA microinjection targeting for each subject determined by post hoc analysis of injection sites. (g) Effects of JZL184 microinfusion into the CeA on freezing during cue-conditioning and short-term extinction sessions. (h) Effects of JZL184 on freezing during a drug-free retrieval test. *P<0.05 significantly different from vehicle treatment by unpaired one-tailed t-test (bar graphs). Error bars represent s.e.m. (a–d) n=12 mice for JZL184 group, and n=9 mice for vehicle group. (e–h) n=19 mice for JZL184 group, and n=10 mice for vehicle group. BLA, basolateral nucleus of the amygdala; CeA, central amygdala.