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. 2016 Mar 22;6(3):e761. doi: 10.1038/tp.2016.27

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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GRS generated from an analysis of AO-AD in a discovery sample, at varying P-value thresholds, predicting (a) AO-AD, (b) AO-I, (c ) AD, (d) AD-SX, (e) Maxdrinks and (f) height in SAGE dataset. The x-axis represents the GRS thresholds and y-axis represents the adjusted R² for the trait. Each bar represents the values of adjusted R² for SAGE. Colors of the bar represent the level of significance achieved. AD, alcohol dependence; AD-SX, total number of DSM4 AD symptoms endorsed; AO-AD, age at onset of AD; AO-I, age at onset of intoxication; GRS, genome-wide polygenic scores; SAGE, Study of Addictions: Genes and Environment.