Figure 2.

Protein–protein interaction network including nonsynonymous DN SNVs in OCD. Genes connecting components of the protein–protein interaction network harbor DN SNVs among the obsessive-compulsive disorder probands (red circles). Genes shaded blue are bridges, linking well-connected regions of the PPI network. Genes shaded orange are brokers, having a large number of connections with non-neighboring genes. Genes within red squares are bottlenecks, connecting different parts of the network with high betweenness. DN SNV, de novo single-nucleotide variant; OCD, obsessive-compulsive disorder; PPI, protein–protein interaction.