Table 2. De novo mutation rate comparisons between our OCD cohort and samples of affected and unaffected individuals evaluated in previous exome-sequencing studies.
| Study | Observed rate | Poisson, P | 95% Confidence interval | Phenotype |
|---|---|---|---|---|
| Sanders et al.10 | 1.31 × 10−8 | 0.02 | 1.1–3.1 | Unaffected sibling of autism proband |
| Sanders et al.10 | 1.58 × 10−8 | 0.89 | 0.93–2.57 | Sporadic autism |
| Iossifov et al.48 | 2.00 × 10−8 | 0.40 | 0.75–1.99 | Sporadic autism |
| O'Roak et al.12 | 2.17 × 10−8 | 0.60 | 0.68–1.84 | Sporadic autism |
| Rauch et al.7 | 1.86 × 10−8 | 0.29 | 0.78–2.23 | Intellectual disability |
| Girard et al.9 | 2.59 × 10−8 | 1 | 0.47–2.05 | Schizophrenia |
| Xu et al.8 | 1.73 × 10−8 | 0.17 | 0.85–2.34 | Schizophrenia |
| Fromer et al.46 | 1.61 × 10−8 | 0.09 | 0.93–2.46 | Schizophrenia |
Abbreviation: OCD, obsessive-compulsive disorder.
Observed rates are de novo variants observed per base pair per generation in the sequenced exome; statistical comparison is between the observed rate and our OCD cohort rate of 2.51 × 10-8 using a two-tailed exact rate ratio test of two Poisson counts; 95% confidence interval is the observed rate/OCD cohort rate.