Table 3. IPA canonical pathway enrichment analysis of PPI network nodes.

IPA pathway	P-value	Overlap	Genes
TGF-β signaling	1.3E−25	26/87	TGFBR1, MAPK1, SMAD3, SKI, SMAD5, MAPK13, TGIF1, EP300, TGFBR2, JUN, RUNX2, SMAD4, NF4A, TFE3, SMAD1, SMAD2, NRAS, SMAD9, FOXH1, CREBBP, SMAD6, SSMAD7, ZNF423, IRF7, RRAS2, PIAS4
BMP signaling pathway	2.5E−15	18/74	RELA, NRAS, SMAD9, MAPK1, CREBBP, SMAD6, SMAD7, PRKAR2A, MAPK13, SMAD5, ATF2, ZNF423, RRAS2, JUN, RUNX2, PRKAR1B, SMAD4, SMAD1
Glucocorticoid receptor signaling	7.1E−12	25/272	RELA, SMAD2, TGFBR1, NRAS, MAPK1, SMAD3, CREBBP, GTF2E2, MAPK13, CEBPB, EP300, TGFBR2, JUN, AKT1, POLR2A, RRAS2, AR, SUMO1, FOXO3, PRKAA2, GTF2H1, SMAD4, STAT1, ESR1, UBE2I

Abbreviations: BMP, bone morphogenic protein; IPA, Ingenuity Pathway Analysis; PPI, protein–protein interaction; TGF-β transforming growth factor beta.

The IPA database contained 320 gene nodes from the PPI network, built from nonsynonymous de novo single-nucleotide variants in obsessive-compulsive disorder probands. The top pathways with the lowest P-values are shown.