Table 2. Difference in DNA methylation levels between neonates born to anxious versus non-anxious mothers, stratified by birth weight.
CpG unit |
Lower birth weight (⩽3530 g) |
Higher birth weight (>3530 g) |
||||
---|---|---|---|---|---|---|
Δ | 95% CI | P | Δ | 95% CI | P | |
IGF2 DMR0 | ||||||
3 | −1.66% | −3.91 to 0.59% | 0.15 | −1.96% | −4.10 to 0.18% | 0.072 |
4 | 0.30% | −2.23 to 2.84% | 0.81 | 0.40% | −2.89 to 3.70% | 0.81 |
6.7 | −0.88% | −2.78 to 1.01% | 0.36 | 0.79% | −0.86 to 2.14% | 0.34 |
Average | −1.00% | −2.71 to 0.70% | 0.25 | −0.09% | −2.04 to 1.85% | 0.92 |
IGF2/H19 ICR | ||||||
1 | −4.33% | −6.83 to −1.84% | 0.0007 | −0.70% | −2.83 to 1.44% | 0.52 |
5.6.7.8 | −3.40% | −5.71 to −1.10% | 0.0040 | −0.45% | −2.63 to 1.73% | 0.68 |
11.12 | −3.82% | −6.10 to −1.55% | 0.0011 | −0.47% | −2.53 to 1.63% | 0.66 |
13.14 | −4.57% | −6.99 to −2.14% | 0.0003 | −0.25% | −2.31 to 1.80% | 0.81 |
21.22 | −3.76% | −6.49 to −1.04% | 0.0071 | 0.27% | −2.35 to 2.88% | 0.84 |
23 | −2.21% | −5.19 to 0.78% | 0.15 | −1.49% | −4.47 to 1.49% | 0.33 |
Average | −3.89% | −6.06 to −1.72% | 0.0005 | −0.59% | −2.54 to 1.37% | 0.55 |
Abbreviations: DMR, differentially methylated region; ICR, imprinting control region.