Table 2. Top 10 SNPs with meta-analysis results of discovery samples, and results of combined discovery and replication samples.

SNP	Chr	BP (hg19)	A1	A2	Freq A1	Discovery			Combineda
						Beta (s.e.)	P-value	Directionb	Beta (s.e.)	P-value
rs4984460	15	96424399	T	G	0.75	−0.11 (.023)	4.6 × 10−7	+−−++−−−−−−−+	−0.11 (0.023)	2.2 × 10−6
rs2099149	12	30479358	T	G	0.81	−0.16 (0.032)	9.8 × 10−7	−−−?−??−?−−+−	−0.17 (0.034)	5.1 × 10−7
rs7675351	4	141218757	A	C	0.86	−0.15 (0.031)	1.4 × 10−6	−−−?+−−−?−−−−	−0.13 (0.033)	1.1 × 10−4
rs4471463	11	112983595	T	C	0.55	−0.09 (0.020)	1.5 × 10−6	−−−−+−+−−−−+−	−0.1 (0.021)	9.0 × 10−7
rs7107977	11	915764	A	G	0.60	0.27 (0.058)	1.9 × 10−6	??+++?+???+?+	0.29 (0.064)	6.4 × 10−6
rs58691539	2	52753909	T	G	0.91	−0.29 (0.062)	2.1 × 10−6	−????−?−????−	−0.29 (0.062)	2.2 × 10−6
rs2033867	2	175188281	A	G	0.06	0.24 (0.051)	2.6 × 10−6	+??????+++??+	0.23 (0.050)	4.2 × 10−6
rs35053471	3	47124761	A	T	0.38	−0.10 (0.022)	2.7 × 10−6	−−−−−?+−−−−−−	−0.09 (0.022)	9.2 × 10−5
rs12518098	5	60864467	C	G	0.68	0.10 (0.022)	3.0 × 10−6	++++−++++++++	0.09 (0.023)	4.7 × 10−5
rs73067624	1	196333461	T	C	0.90	−0.18 (0.039)	3.1 × 10−6	−?−?−−−−?−−−−	−0.16 (0.041)	6.3 × 10−5

Abbreviations: A1, allele 1; A2, allele 2; BP (hg19), location in base pairs in human genome version 19; Chr, chromosome; Freq A1, frequency of allele 1; SNP, single-nucleotide polymorphism.

^aThe combined sample contains the discovery samples and the Radar, SYS and TwinsUK replication samples.

^bDirection per sample: allele A1 increases (+) or decreases (−) liability for cannabis use, or sample did not contribute to this SNP because it did not pass the post-imputation quality control (?). Order of samples: ALSPAC, BLTS, CADD, EGCUT1, EGCUT2, FinnTwin, HUVH, MCTFR, NTR, QIMR, TRAILS, Utrecht, Yale Penn EA. Sample information can be found in Table 1.

SNPs are displayed when not in linkage disequilibrium (R²<0.1. For SNPs with R²⩾0.1, only the most significant SNP is shown in the top 10).