Table 2. CSF levels of amino acids and ratio of amino acids in subjects at baseline.
Characteristic | Comparison group at baseline (N=19) | MDD group at baseline (N=28) | Analysis | ||
---|---|---|---|---|---|
t | df | P | |||
Glutamine | 568.17±81.19 | 591.04±87.78 | 0.903 | 45 | 0.371 |
Glutamate | 0.647±0.82 | 0.382±0.11 | 1.407 | 18.5a | 0.176 |
Glycine | 12.99±5.95 | 11.38±2.67 | 1.103 | 23.0a | 0.282 |
l-Serine | 25.45±5.58 | 22.36±5.13 | 1.955 | 45 | 0.057 |
d-Serine | 1.76±0.38 | 1.75±0.43 | 0.093 | 45 | 0.926 |
Glutamine/glutamate | 1257.6±458.4 | 1645.6±434.7 | 2.938 | 45 | 0.005b |
Glycine/l-serine | 0.496±0.14 | 0.526±0.14 | 0.7 | 45 | 0.488 |
d-Serine/l-serine | 0.072±0.021 | 0.080±0.019 | 1.326 | 45 | 0.192 |
Abbreviations: CSF, cerebrospinal fluid; df, degrees of freedom; MDD, major depressive disorder.
Bold P-values indicate statistically significant. The data are mean±s.d.
Equality of variance assumption not met.
Denotes significant finding at α=0.006 after Sidak's adjustment (eight tests).