Table 2. CSF levels of amino acids and ratio of amino acids in subjects at baseline.

Characteristic	Comparison group at baseline (N=19)	MDD group at baseline (N=28)		Analysis
			t	df	P
Glutamine	568.17±81.19	591.04±87.78	0.903	45	0.371
Glutamate	0.647±0.82	0.382±0.11	1.407	18.5a	0.176
Glycine	12.99±5.95	11.38±2.67	1.103	23.0a	0.282
l-Serine	25.45±5.58	22.36±5.13	1.955	45	0.057
d-Serine	1.76±0.38	1.75±0.43	0.093	45	0.926
Glutamine/glutamate	1257.6±458.4	1645.6±434.7	2.938	45	0.005b
Glycine/l-serine	0.496±0.14	0.526±0.14	0.7	45	0.488
d-Serine/l-serine	0.072±0.021	0.080±0.019	1.326	45	0.192

Abbreviations: CSF, cerebrospinal fluid; df, degrees of freedom; MDD, major depressive disorder.

Bold P-values indicate statistically significant. The data are mean±s.d.

^aEquality of variance assumption not met.

^bDenotes significant finding at α=0.006 after Sidak's adjustment (eight tests).