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. 2016 Apr 28;15(6):1144–1160. doi: 10.1016/j.celrep.2016.04.029

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© 2016 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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mTOR Inhibition Disrupts Metabolic Symbiosis

(A) Evaluation by tissue immunostaining of MCT1 (red) and MCT4 (green) expression in representative tumors treated with Mono-R or Mono-S (top row) or with the combination (bottom row). The Mono-R-treated tumors (top left) appear similar to control vehicle-treated tumors (Figures 2F and S7) in having relatively weak expression of the MCT1/4 transporters. In the R+S-treated tumors (bottom), MCT4-expressing regions (green) are reduced versus MCT1-expressing regions, which have expanded (red), in contrast, note relatively more expanded MCT4-positive regions in Mono-S-treated tumors (top: center and right: green). The scale bar represents 100 μm. See also Figure S7.

(B) In contrast to the overlapping distribution between GLUT1 (red) and hypoxia (pimo, green) in both Mono-S and R+S-treated tumors (top row), GLUT2 (red) is selectively upregulated in the non-hypoxic compartment of R+S-treated tumors (bottom row). The scale bars represent 25 μm. See also Figure S5B.