Table 3.
Association between total number of infrequent TRIB3 variants and CAD in the three study sets.
| Study name |
Study country |
Variants (n) |
Control n (%) |
Case n (%) |
OR (95% CI) | p value for OR heterogeneity |
|---|---|---|---|---|---|---|
| 0 | 242 (91.7) | 208 (95.9) | 0.47(0.22–1.00) | |||
| GHS | Italy | 1 | 20 (7.6) | 9 (4.1) | ||
| 2 | 2 (0.7) | 0 | p=0.05 | NE | ||
| 0 | 135 (97.8) | 81 (100) | ||||
| CS | Italy | 1 | 3 (2.2) | 0 | NE | |
| 2 | 0 | 0 | p=0.30* | |||
| 0 | 377 (93.8) | 289 (97.0) | 0.43 (0.20–0.91) | |||
| GHS+CS | Italy | 1 | 23 (5.7) | 9 (3.0) | p=0.03 | |
| 2 | 2 (0.5) | 0 | 0.03 | |||
| 0 | 426 (95.1) | 393 (94.2) | 1.22 (0.69–2.18) | |||
| JHS | U.S. | 1 | 22 (4.9) | 23 (5.6) | p=0.49 | |
| 2 | 0 | 1 (0.2) | ||||
GHS: Gargano Heart Study; CS: Catanzaro Study; JHS: Joslin Heart Study.
NE: not estimable, due to the lack of variants among cases.
*
as estimated by Fisher exact test