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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Biomaterials. 2015 Dec 29;82:94–112. doi: 10.1016/j.biomaterials.2015.12.025

Fig. 10.

Fig. 10

(A) A coacervate can be self-assembled by mixing PEAD and heparin. Embedding VEGF in a fibrin gel and PDGF in a coacervate that is distributed in the same gel leads to a (B) sequential release of VEGF followed by PDGF. (C) Sequential delivery of VEGF and PDGF significantly improves cardiac function in rats compared to saline, empty delivery vehicle, and free proteins. (D) Hematoxylin and eosin (H&E) staining shows significant damage of heart morphology, dilation, wall thinning, scar expansion, and granulated tissue in saline control compared to significant reduction of damage due to sequential delivery after MI.