Table 1. Characteristics of the PPIN analyzed in this paper.
| Name | Nodes | Edges | Diameter | Eccentricity (median) |
|---|---|---|---|---|
| Full Undirected Network | 16,857 | 264,845 | ||
| Filtered Undirected Network | 15,582 | 249,102 | ||
| Directed Network | 15,582 | 249,102 | 8 | 5 |
| Critical nodes | 4525 (29%) | nd | 5 | |
| Redundant nodes | 7256 (47%) | nd | 6 | |
| Ordinary nodes | 3801 (24%) | nd | nd | |
| Top ten critical nodes | ||||
| Node name | k | k_in | k_out | |
| 14-3-3γ | 565 | 271 | 294 | |
| 14-3-3β | 534 | 240 | 294 | |
| 14-3-3ϑ | 447 | 63 | 384 | |
| 14-3-3η | 299 | 127 | 172 | |
| 14-3-3ε | 506 | 232 | 274 | |
| 14-3-3ζ | 948 | 393 | 555 | |
| 14-3-3σ | 276 | 123 | 153 | |
| PAXI1 | 329 | 98 | 231 | |
| ZBT16 | 146 | 98 | 48 | |
| Angiomotin | 135 | 65 | 70 | |
nd = not determined.