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. 2016 May 19;6:26236. doi: 10.1038/srep26236

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Copyright © 2016, Macmillan Publishers Limited

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(a,b) Functional analyses by use of CRE-luc reporter gene assay and BHK cells stably over-expressing human GLP-1R and cAMP response element (CRE) coupled to firefly luciferase (CRE luc). (a) Concentration-response curves induced by native GLP-1, the short GLP-1 analogue BMS21 and the small molecule compound 2. Data are normalized to maximum response of GLP-1. (b) Influence of increasing Fab 3F52 concentrations on CRE-luc activity triggered by stimulation with EC₈₀ of native GLP-1, BMS21 and compound 2. Fab 3F52 reveals concentration-dependent inhibition of GLP-1 and BMS21, but not compound 2. (a,b) Depicted values represent mean ± SEM of at least three independent experiments.