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. Author manuscript; available in PMC: 2016 May 19.
Published in final edited form as: Pharm Res. 2007 Oct 3;25(1):194–206. doi: 10.1007/s11095-007-9451-9

Table III.

Pharmacokinetics of Paclitaxel After iv Administration of Control Taxol® (Paclitaxel in Cremophor EL:Ethanol); Paclitaxel and PAX7′C6 After iv Administration of Control PAX7′C6 in Cremophor EL:Ethanol; and Paclitaxel and PAX7′C6 after iv Administration of PAX7′C6 in PEG-b-PCL. The Intravenous Dose for all the Formulations was 10 mg/kg to Rats (mean±SEM, n =10 per group)

Pharmacokinetic Parameter Paclitaxel from Taxol® Control Paclitaxel from PAX7′C6 in CrEL:EtOH Paclitaxel from PAX7′C6 in PEG-b-PCL PAX7′C6 from PAX7′C6 in CrEL:EtOH PAX7′C6 from PAX7′C6 in PEG-b-PCL
AUCinf (μgh/ml) 7.194 ± 1.495 1.519 ± 0.235a 51.113 ± 1.362b,c 16.247 ± 3.062 392.758 ± 31.501d
Vdβ (L/kg) 3.377 ± 0.687 13.125 ± 1.498a 1.602 ± 0.504b,c 4.678 ± 0.765 0.259 ± 0.030d
CLrenal (L/h/kg) 0.900 ± 0.203 0.635 ± 0.072 0.014 ± 0.002b,c 0.004 ± 0.001 3.378 × 10−06 ± 4.291 × 10−07d
CLhepatic (L/h/kg) 0.655 ± 0.220 6.274 ± 1.094a 0.182 ± 0.004b,c 0.656 ± 0.121 0.026 ± 0.002d
CLtot (L/h/kg) 1.556 ± 0.400 6.909 ± 1.070a 0.196 ± 0.005b,c 0.661 ± 0.122 0.026 ± 0.002d
Fe (%) 58.913 ± 5.953 9.695 ± 1.805a 6.959 ± 0.851b 0.656 ± 0.081 0.014 ± 0.003d
KE (h−1) 0.453 ± 0.033 0.522 ± 0.022 0.145 ± 0.036b,c 0.145 ± 0.027 0.101 ± 0.007
t1/2 (h) serum 1.548 ± 0.122 1.333 ± 0.055 5.602 ± 1.656b,c 5.131 ± 0.989 6.946 ± 0.479
t1/2 (h) urine 10.932 ± 2.091 10.898 ± 1.526 15.827 ± 0.808b,c 7.042 ± 0.290 17.102 ± 1.947d
MRT (h) 1.100 ± 0.214 1.912 ± 0.103a 4.291 ± 0.767b,c 7.635 ± 1.107 4.138 ± 0.380d
Extraction ratio (ER) 0.377 ± 0.126 3.606 ± 0.628a 0.105 ± 0.002b,c 0.377 ± 0.070 0.015 ± 0.001d
a

Denotes statistical significant difference (P< 0.05) between paclitaxel after iv administration of control Taxol® (paclitaxel in Cremophor EL:Ethanol) and paclitaxel after iv administration of control PAX7′C6 in Cremophor EL:Ethanol.

b

Denotes statistical significant difference (P < 0.05) between paclitaxel after iv administration of control Taxol® (paclitaxel in Cremophor EL:Ethanol) and paclitaxel after iv administration of PAX7′C6 in PEG-b-PCL.

c

Denotes statistical significant difference (P < 0.05) between paclitaxel after iv administration of control PAX7′C6 in Cremophor EL:Ethanol and paclitaxel after iv administration of PAX7′C6 in PEG-b-PCL.

d

Denotes statistical significant difference (P < 0.05) between PAX7′C6 after iv administration of control PAX7′C6 in Cremophor EL:Ethanol and PAX7′C6 after iv administration of PAX7′C6 in PEG-b-PCL.