. Author manuscript; available in PMC: 2016 May 19.

Published in final edited form as: Pharm Res. 2007 Oct 3;25(1):194–206. doi: 10.1007/s11095-007-9451-9

Table IV. Mean Concentrations (μg/g of Tissue) of Paclitaxel and PAX7′C₆ in Rat Tissues (and Tissue to Serum Ratios—Kp Values—in Parenthesis) Measured at 6 h post iv Administrations of Control Taxol^® (Paclitaxel in Cremophor EL/Ethanol) and PAX7′C₆ in PEG-b-PCL in Plasma after iv Administration (10 mg/kg; mean ± SEM, n =4).

Tissue	Paclitaxel from Taxol^® Control	Paclitaxel from PAX7′C₆ in PEG-b-PCL	PAX7′C₆ from PAX7′C₆ in PEG-b-PCL
Serum	0.066 ± 0.003	0.464 ± 0.095^a	10.062 ± 0.913^b^,^c
Whole Blood	1.463 ± 0.097 (22.110 ± 1.473)	0.332 ± 0.139^a (0.716 ± 0.300)^a	14.730 ± 5.954^b^,^c (1.464 ± 0.592)^b
Liver	17.042 ± 5.559 (257.498 ± 83.988)	1.171 ± 0.184^a (2.526 ± 0.396)^a	23.053 ± 7.598 (2.291 ± 0.755)^b
Kidney	3.989 ± 1.221 (60.272 ± 18.449)	0.669 ± 0.147^a (1.445 ± 0.317)^a	19.129 ± 4.109^b^,^c (1.901 ± 0.408)^b
Spleen	33.419 ± 0.543 (504.942 ± 8.198)	0.274 ± 0.078^a (0.592 ± 0.168)^a	14.397 ± 2.556^b^,^c (1.431 ± 0.254)^b^,^c
Brain	<0.02 (<0.30)	0.736 ± 0.181^a (1.587 ± 0.390)^a	0.707 ± 0.191^b (0.070 ± 0.019)^b^,^c
Muscle	12.056 ± 3.054 (182.155 ± 46.139)	0.323 ± 0.025^a (0.696 ± 0.054)^a	9.884 ± 1.589^c (0.982 ± 0.158)^b^,^c
Lung	16.425 ± 5.098 (248.170 ± 77.028)	0.606 ± 0.126^a (1.307 ± 0.271)^a	33.399 ± 9.000^b^,^c (3.319 ± 0.894)^b^,^c
Heart	11.066 ± 2.561 (167.200 ± 38.698)	0.294 ± 0.065^a (0.635 ± 0.140)^a	12.086 ± 2.503^c (1.201 ± 0.249)^b^,^c
Urinary bladder	7.651 ± 0.577 (115.603 ± 8.712)	0.313 ± 0.072^a (0.674 ± 0.155)^a	12.643 ± 2.682^b^,^c (1.256 ± 0.267)^b^,^c

Denotes statistical significant difference (P < 0.05) between paclitaxel after iv administration of control Taxol^® (paclitaxel in Cremophor EL:Ethanol) and paclitaxel after iv administration of PAX7′C₆ in PEG-b-PCL.

Denotes statistical significant difference (P < 0.05) between paclitaxel after iv administration of control Taxol^® (paclitaxel in Cremophor EL:Ethanol) and PAX7′C₆ after iv administration of PAX7′C₆ in PEG-b-PCL.

Denotes statistical significant difference (P < 0.05) between paclitaxel after iv administration of PAX7′C₆ in PEG-b-PCL and PAX7′C₆ after iv administration of PAX7′C₆ in PEG-b-PCL.