. Author manuscript; available in PMC: 2016 May 19.

Published in final edited form as: Pharm Res. 2007 Oct 3;25(1):194–206. doi: 10.1007/s11095-007-9451-9

Table V. Mean Concentrations (μg/g of Tissue) of Paclitaxel and PAX7′C₆ in Rat Tissues (and Tissue to Serum Ratios—Kp Values—in Parenthesis) Measured at 24 h Post iv Administrations of Control Taxol^® (Paclitaxel in Cremophor EL:Ethanol) and PAX7′C₆ in PEG-b-PCL in Plasma after iv Administration (10 mg/kg; mean±SEM, n =4).

Tissue	Paclitaxel from Taxol^® Control	Paclitaxel from PAX7′C₆ in PEG-b-PCL	PAX7′C₆ from PAX7′C₆ in PEG-b-PCL
Serum	0.036 ± 0.001	0.021 ± 0.002^a	0.163 ± 0.012^b^,^c
Whole Blood	0.039 ± 0.001 (1.104 ± 0.065)	0.074 ± 0.002^a (2.984 ± 0.088)^a	0.173 ± 0.032^b^,^c (1.042 ± 0.113)^c
Liver	4.801 ± 0.828 (132.581 ± 13.956)	1.049 ± 0.222^a (49.018 ± 2.024)^a	3.140 ± 0.333^b^,^c (17.986 ± 0.803)^b^,^c
Kidney	9.243 ± 1.593 (264.888 ± 36.473)	1.009 ± 0.002^a (48.941 ± 8.316)^a	4.474 ± 0.361^b^,^c (28.164 ± 5.921)^b^,^c
Spleen	20.784 ± 6.064 (593.083 ± 153.607)	1.034 ± 0.208^a (44.401 ± 5.513)^a	7.075 ± 0.541^b^,^c (44.515 ± 9.180)^b
Brain	0.239 ± 0.029 (6.950 ± 1.091)	<0.02^a (<0.96)^a	1.319 ± 0.021^b^,^c (7.595 ± 0.347)^c
Muscle	1.482 ± 0.396 (42.159 ± 13.910)	0.653 ± 0.045^a (31.283 ± 3.234)	2.136 ± 0.022^b^,^c (13.288 ± 1.613)^b^,^c
Lung	59.914 ± 10.542 (1716.809 ± 242.728)	1.690 ± 0.114^a (82.918 ± 19.619)^a	12.713 ± 1.240^b^,^c (80.212 ± 18.158)^b
Heart	13.094 ± 2.659 (354.878 ± 83.265)	1.056 ± 0.161^a (49.869 ± 0.966)^a	3.875 ± 1.288^b^,^c (23.084 ± 4.842)^b^,^c
Urinary bladder	5.841 ± 0.430 (164.041 ± 23.201)	3.602 ± 0.395^a (189.009 ± 38.093)	6.231 ± 0.321^c (38.553 ± 3.115)^b^,^c

Denotes statistical significant difference (P < 0.05) between paclitaxel after iv administration of control Taxol^® (paclitaxel in Cremophor EL:Ethanol) and paclitaxel after iv administration of PAX7′C₆ in PEG-b-PCL.

Denotes statistical significant difference (P < 0.05) between paclitaxel after iv administration of control Taxol^® (paclitaxel in Cremophor EL:Ethanol) and PAX7′C₆ after iv administration of PAX7′C₆ in PEG-b-PCL.

Denotes statistical significant difference (P <0.05) between paclitaxel after iv administration of PAX7′C₆ in PEG-b-PCL and PAX7′C₆ after iv administration of PAX7′C₆ in PEG-b-PCL.