Table 1.

Respiratory parameters of glutamate/malate-respiring rat brain mitochondria (2 mg protein per mL) in the absence (Control) or in the presence of 1 mM L-tryptophan (L-TRP) or its metabolites L-kynurenine (L-KYN), kynurenic acid (KYNA), anthranilic acid (ANA), 3-hydroxykynurenine (3-OH-KYN), 3-hydroxyanthranilic acid (3-OH-ANA), xanthurenic acid (XAN) and quinolinic acid (QUIN), respectively.

SUBSTANCES	STATE 2	STATE 3	RC	ADP/O
Control	4.97 ± 0.30	23.4 ± 1.3	4.76 ± 0.29	2.24 ± 0.15
L-TRP	4.67 ± 0.30	22.7 ± 1.1	4.94 ± 0.11	2.21 ± 0.15
QUIN	4.90 ± 0.36	22.8 ± 1.2	4.70 ± 0.15	2.29 ± 0.17
ANOVA, F	0.231	0.089	0.403	0.071
P	0.797	0.915	0.675	0.932
Control	5.28 ± 0.37	21.7 ± 1.9	4.11 ± 0.12	2.49 ± 0.04
L-KYN	5.34 ± 0.44	22.3 ± 1.8	4.19 ± 0.15	2.44 ± 0.04
3-OH-KYN	5.64 ± 0.55	20.6 ± 1.9	3.67 ± 0.11*	2.27 ± 0.05**
ANOVA, F	0.169	0.209	4.763	6.831
P	0.846	0.814	0.025	0.0078
Control	4.42 ± 0.47	15.6 ± 1.9	3.55 ± 0.27	2.23 ± 0.06
KYNA	4.80 ± 0.30	16.3 ± 1.5	3.41 ± 0.25	2.21 ± 0.07
ANA	4.37 ± 0.27	13.1 ± 1.3	2.98 ± 0.22	2.19 ± 0.05
ANOVA, F	0.442	1.116	1.449	0.095
P	0.651	0.353	0.266	0.910
Control	4.84 ± 0.55	22.1 ± 2.8	4.54 ± 0.11	2.31 ± 0.07
3-OH-ANA	6.53 ± 0.85	20.3 ± 2.6	3.14 ± 0.12***	2.12 ± 0.08
XAN	5.10 ± 0.83	20.2 ± 2.8	4.03 ± 0.16*	2.36 ± 0.09
ANOVA, F	1.440	0.142	29.514	2.417
P	0.268	0.869	<0.001	0.123

Notes: States are given in nmol O × min⁻¹ × mg⁻¹. Data are means ± S.E.M; n = 6;

^*P < 0.05,

^**P < 0.01;

^***P < 0.001 in comparison to the respective control.