Table 2.

Respiratory parameters of rotenone-inhibited succinate-respiring rat brain mitochondria (2 mg protein per mL) in the absence (Control) or in the presence of 1 mM L-tryptophan (L-TRP) or its metabolites L-kynurenine (L-KYN), kynurenic acid (KYNA), anthranilic acid (ANA), 3-hydroxykynurenine (3-OH-KYN), 3-hydroxyanthranilic acid (3-OH-ANA), xanthurenic acid (XAN) and quinolinic acid (QUIN), respectively.

SUBSTANCES	STATE 2	STATE 3	RC	ADP/O
Control	8.25 ± 0.38	33.7 ± 1.3	4.10 ± 0.11	1.56 ± 0.05
L-TRP	8.24 ± 0.50	33.2 ± 1.3	4.08 ± 0.13	1.51 ± 0.04
QUIN	8.22 ± 0.34	33.6 ± 1.4	4.09 ± 0.07	1.51 ± 0.06
ANOVA, F	0.0014	0.030	0.017	0.305
P	0.999	0.970	0.983	0.742
Control	7.20 ± 0.81	33.3 ± 3.0	4.70 ± 0.12	1.39 ± 0.02
L-KYN	7.44 ± 0.62	33.4 ± 2.1	4.54 ± 0.13	1.33 ± 0.01
3-OH-KYN	9.22 ± 0.83	31.9 ± 3.2	3.48 ± 0.10***	1.10 ± 0.02***
ANOVA, F	2.123	0.090	32.786	56.241
P	0.154	0.914	<0.001	<0.001
Control	6.99 ± 0.36	28.6 ± 2.2	4.08 ± 0.22	1.35 ± 0.01
KYNA	6.54 ± 0.41	27.2 ± 1.9	4.17 ± 0.23	1.31 ± 0.02
ANA	6.57 ± 0.42	26.9 ± 2.0	4.13 ± 0.17	1.37 ± 0.02
ANOVA, F	0.397	0.197	0.048	2.872
P	0.679	0.823	0.953	0.088
Control	8.38 ± 1.12	33.3 ± 3.7	4.04 ± 0.14	1.47 ± 0.04
3-OH-ANA	10.65 ± 1.16	33.4 ± 3.6	3.14 ± 0.08***	1.26 ± 0.03**
XAN	8.36 ± 1.41	32.4 ± 3.7	4.04 ± 0.22	1.46 ± 0.05
ANOVA, F	1.131	0.020	10.847	8.051
P	0.349	0.980	0.0012	0.0042

Notes: States are given in nmol O × min⁻¹ × mg⁻¹. Values represent means ± S.E.M; n = 6;

^**P < 0.01;

^***P < 0.001 in comparison to the respective control.