Table 3.

Respiratory parameters of glutamate/malate-respiring rat liver mitochondria (1 mg protein per mL) in the absence (Control) or in the presence of 1 mM L-tryptophan (L-TRP) or its metabolites L-kynurenine (L-KYN), kynurenic acid (KYNA), anthranilic acid (ANA), 3-hydroxykynurenine (3-OH-KYN), 3-hydroxyanthranilic acid (3-OH-ANA), xanthurenic acid (XAN) and quinolinic acid (QUIN), respectively.

SUBSTANCES	STATE 2	STATE 3	RC	ADP/O
Control	15.7 ± 1.4	63.6 ± 3.2	4.14 ± 0.21	2.27 ± 0.19
L-TRP	15.7 ± 1.7	60.3 ± 4.3	3.94 ± 0.18	2.26 ± 0.19
QUIN	14.5 ± 1.3	60.8 ± 4.3	4.23 ± 0.13	2.29 ± 0.18
ANOVA, F	0.212	0.207	0.725	0.0058
P	0.811	0.815	0.500	0.994
Control	13.1 ± 0.7	52.1 ± 2.7	3.98 ± 0.16	2.57 ± 0.07
L-KYN	13.3 ± 0.7	52.6 ± 3.2	3.96 ± 0.14	2.60 ± 0.05
3-OH-KYN	15.4 ± 0.9	50.5 ± 3.9	3.28 ± 0.15**	2.53 ± 0.06
ANOVA, F	2.601	0.106	7.114	0.397
P	0.107	0.900	0.0067	0.679
Control	12.7 ± 0.8	53.3 ± 3.6	4.22 ± 0.20	2.51 ± 0.08
KYNA	14.1 ± 0.7	51.6 ± 3.6	3.67 ± 0.17	2.44 ± 0.10
ANA	13.7 ± 0.6	50.3 ± 3.9	3.67 ± 0.18	2.42 ± 0.07
ANOVA, F	0.957	0.157	2.877	0.369
P	0.406	0.856	0.088	0.698
Control	11.4 ± 0.5	49.0 ± 1.7	4.35 ± 0.18	2.51 ± 0.05
3-OH-ANA	13.3 ± 0.6*	48.7 ± 2.5	3.69 ± 0.11*	2.29 ± 0.07*
XAN	11.2 ± 0.7	45.3 ± 2.5	4.07 ± 0.25	2.52 ± 0.11
ANOVA, F	3.646	0.835	3.167	2.826
P	0.051	0.453	0.071	0.091

Notes: States are given in nmol O × min⁻¹ × mg⁻¹. Values represent means ± S.E.M; n = 6;

^*P < 0.05,

^**P < 0.01 in comparison to the respective control.