Figure 4.

Forest plots showing Löfgren’s syndrome (LS) and non-LS single-nucleotide polymorphism (SNP) associations outside the major histocompatibility complex. Plots show the study-specific association estimates (odds ratio) and 95% confidence intervals (CIs) for discovery set (Swedish) and replication studies (German, African American [USA-AA], Dutch, Czech). Results for LS-associated SNPs rs133409913, rs9295661, and rs10108612 are shown in the top. Results for non-LS–associated SNP rs1953600, rs2573346, and rs1049550 are shown in the bottom. The association estimate and CI (estimated under fixed-effect model) for the meta-analysis combining the discovery and replicating cohort are shown as a diamond. Blank spaces indicate occasions in which a particularly study was not able to provide results for a given SNP. I² indicates the percentage of total variation in study estimates because of heterogeneity in the meta-analysis.