Skip to main content
. 2016 Feb 2;7(6):6369–6378. doi: 10.18632/oncotarget.7141

Figure 4. The detection limit of CEST MRI for detecting gemcitabine.

Figure 4

a. The calibration curves of the CEST signal of gemcitabine at concentrations ranging from 0.5 to 20 mM in PBS; b. The CEST MRI contrast at 2.2 ppm for samples prepared in 1% and 2% agarose gels, the CEST contrast in PBS is shown for comparison; c. Bar plots of the CEST contrast at different concentrations in each sample. A two-tailed paired Student's t-test was performed (**p < 0.01 and *P < 0.05). The results are mean ± SD (n = 3); d. Bar plots of the ΔCNR for samples containing gemcitabine at different concentrations as compared to reference samples containing 1% or 2% agarose gel. The horizontal dashed line represents ΔCNR = 2√2.