Figure 3. MiRNA regulation of target genes.
A. and B. The most frequently validated miRNA and target genes. C. The enlarged leading miRNA-targets nodes generated using the validated miRNA-target pairs. The network edges are coded by degree of expressional miRNA-mRNA associations obtained in TCGA CRC patients. MiRNA nodes are indicated by rectangles, target nodes as ovals. Size of nodes reflects the number of connections, with bigger nodes representing more densely connected regions. The node of miR-143/miR-145-KRAS should be taken with precaution in light of the recent results by Chivukala et. al.[105].