Table 1. Tissue miRNAs as potential biomarkers for Colorectal Cancer (CRC).

Application	miRNA biomarker	Type of analysis*	Total nr of samples#	Ref.
	MIRNA BIOMARKERS IN TISSUE BIOPSIES		specimens #
Anti-angiogenetic therapy	miR-126	↑	109	[172]
Anti-EGFR therapy	let-7a	↑	59	[173]
	let-7c, miR-99a, miR-125b	signature	183	[174]
	miR-7	↓	105	[58]
	miR-31-5p	↑	102	[175]
	miR-125b, miR-137	↑	66	[176]
Chemotherapy	let-7g, miR-132, miR-224, miR-320a	signature	128	[177]
	miR-16, miR-590-5p, miR-153, miR-519c-3p, miR-561	signature	32	[178]
	miR-17-5p	↑	390	[179]
	miR-21	↑	84	[180]
	miR-21	↑	301	[181]
	miR-21, miR-143, miR-145	expression, diverse	120	[116]
	miR-107, miR-99a-3a	↑	78	[182]
	miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909*, miR-630, miR-765, miR-622, miR-630	signature	37	[183]
	miR-126	expression, not significant	158	[184]
	miR-143	↓	175	[185]
	miR-148a	↓, methylation	293	[186]
	miR-148b	↓	192	[187]
	miR-150	↓	625	[54]
	miR-181d, miR-139-3p, miR-892b, miR-338-5p, miR-150, miR-154,miR-454	signature	70	[188]
	miR-200a, miR-200c, miR-141, miR-429	↓	127	[189]
	miR-200c	↓	103	[190]
	miR-214	↓	242	[191]
	miR-215	↑	48	[192]
	miR-215, miR-190b, miR-29b-2*, miR-196b, let-7e, miR-450a, miR-450b-5p, miR--99a*	signature	20	[193]
	miR-320	↓	100	[194]
	miR-451	↓	35	[195]
	miR-622	↑	17	[55]
	miR-625-3p, miR-181b, miR-27b	↑	283	[196]
Diagnosis	miR-21	↑	360	[197]
	miR-21	↑	73	[198]
	miR-31	↑	1382	[46]
	miR-34b	↓, methylation	113	[199]
	miR-155	↑	80	[200]
	miR-194	↓	446	[201]
	miR-375, miR-424, miR-92a	signature	282	[64]
	miR-378*, miR-145	↓	64	[202]
Prognosis/Survival /Metastasis	miR-21	↑	554	[203]
	miR-21	↑	412	[204]
	miR-21	↑	392	[205]
	miR-21	↑	7 studies	[206]
	miR-21	↑	14 studies	[207]
	miR-21, miR-155	↑	312	[208]
	miR-21-5p, miR-20a-5p, miR-103a-3p, miR-106b-5p, miR-143-5p, miR-215	signature	775	[209]
	let-7a	↓	40	[210]
	let-7c	↓	254	[211]
	miR-1, miR-129, miR-215, miR-497, miR-135b, miR-493	signature	49	[212]
	miR-101	↓	36	[213]
	miR-106a, miR-143, miR-125b	expression, diverse	48	[214]
	miR-126	↓	560	[215]
	miR-130b	↑	160	[216]
	miR-139-3p	↓	126	[217]
	miR-139-5p, miR-31, miR-17-92, miR-143, miR-10b	signature	142	[218]
	miR-143	↓	154	[219]
	miR-148a, miR-152	↓	202	[220]
	miR-15, miR-16	↓	126	[221]
	miR-15b, miR-135b	↓	189	[222]
	miR-17-92, miR-17	↑	48	[223]
	miR-182	↑	296	[52]
	miR-182	↑	176	[75]
	miR-183	↑	188	[224]
	miR-195	↓	170	[225]
	miR-195, miR-1280, miR-140-3p, miR-1246	signature	19	[226]
	miR-196a, miR-196b	↑	252	[227]
	miR-200a, miR-17, miR-106a, miR-375, miR-29a, miR-18a, miR-200b	signature	267	[228]
	miR-215	↑	116	[229]
	miR-224	↑	230	[230]
	miR-338-3p	↓	80	[231]
	miR-340	↓	155	[232]
	miR-34-5p	↓	278	[28]
	miR-375	↓	190	[233]
	miR-429	↑	214	[234]
	miR-638	↓	312	[70]
	miR-21	↑	20	[235]
	miR-21, miR-103, miR-93, miR-566	signature	187	[236]
	miR-25-3p, miR-339-5p	↓	93	[237]
	miR-27a	↓	82	[238]
	miR-122	↑	12	[239]
	miR-133a	↓	338	[240]
	miR-133b	↓	62	[241]
	miR-133b	↓	100	[242]
	miR-185	↓	40	[243]
	miR-185, miR133b	expression, diverse	50	[244]
	miR-193a-5p	↓	360	[245]
	miR-199a-5p	↓	20	[246]
	miR-200b, miR-200c	↓	13	[247]
	miR-210	↑	193	[248]
	miR-210, miR-133b	expression, diverse	54	[249]
	miR-224	↓	158	[250]
	miR-224, miR-221*	↓	60	[251]
	miR-625	↓	192	[252]
	miR-21	↑	277	[253]
	miR-29a	↓	110	[254]
	miR-215	↓	125	[255]

* ↑, upregulated expression in CRC vs. normal control; ↓, downregulated expression in CRC vs. normal control; methylation, cancer specific DNA methylation; signature, multiple miRNAs considered collectively; expression, diverse, multiple miRNAs considered separately, #total number of samples included in the study, CRCs, adenomas and normal control samples collectively; specimens #1 – tissue samples from normal colonic mucosa, adenomas and cancer biopsies.