Skip to main content
. 2015 Oct 23;7(6):6576–6592. doi: 10.18632/oncotarget.5878

Figure 2. Effect of MLN0128 on c-Myc expression and Akt/mTOR pathway in MCC xenograft tumors.

Figure 2

A. Suppressed c-Myc expression by Western blotting in MCC-3 and MCC-5 cells after MLN0128 treatment. B. MLN0128 suppresses phosphorylation of Akt, mTOR and its downstream molecules 4E-BP1 and S6 in MCC-2, MCC-3, and MCC-5 xenograft tumors. Western blot analysis was performed with indicated antibodies. Tubulin was used as a loading control. C. MLN0128 suppresses phosphorylation of Akt, mTOR and its downstream molecules 4E-BP1 and S6 in MKL-1 xenograft tumors. Western blotting was performed with indicated antibodies. Actin was used as loading control.