Figure 3. The mutation spectrum of the mt genome suggests replication-dependent DNA damage and does not change at relapse.

Primary and relapsed tumors are compared. The 6 base substitutions classes are indicated on the top and the bases flanking the substitutions 5′ and 3′ are depicted at the bottom. The percentages show the observed frequencies of the base substitutions within their sequence context normalized by the frequency seen in the Revised Cambridge Reference Sequence (rCRS) of the mt genome.