Table 1. Number of tumor-specific and germline mt variants with corresponding differences and coefficients.

Patient	Tumor-specific mt variants (n)a		Differenceb	Germline mt variants (n)c		Coefficientd
	P	R		P	R
1	10	4	−6	187	51	−175.5
2	0	16	16	5	66	−62.0
3	4	19	15	191	30	−6.0
4	0	19	19	10	160	40.5
5	4	19	15	265	223	−64.0
6	0	0	0	219	110	−23.5
7	0	21	21	3	84	−1.0
8	0	6	6	36	115	40.5
9	9	10	1	277	231	12.5
10	0	0	0	55	59	−110.0
11	2	12	10	3	62	−32.5
12	2	2	0	51	49	−138.5
13	12	14	2	219	113	15.0
14	0	1	1	1	2	−3.0
15	3	4	1	350	172	−135.5
16	2	6	4	141	55	−74.5

^aNumber of tumor-specific mt variants: P, primary tumor; R, relapse tumor. Variants with an allele frequency of at least 1% were analyzed.

^bDifference: Pairwise difference between primary and relapse tumor.

^cNumber of germline mt variants: P, primary tumor; R, relapse tumor. Variants with an allele frequency of at least 1% were analyzed.

^dCoefficient: Coefficient as calculated by linear regression.